UniProt Accession

 R7BP_MOUSE; Q8BQP9; Q0VF69; Q3UVC4; Q8CBD6; Q9CTP1 

Genbank Protein ID

 DQ104214; AK020910; AK036240; AK046733; AK137417; BC118957 

Genbank Nucleotide ID

 AAZ09201.1; BAB32250.1; BAC29358.1; BAC32849.1; BAE23346.1; AAI18958.1 

Protein Name

 Regulator of G-protein signaling 7-binding protein 

Protein Synonyms/Alias

 R7 family-binding protein 

Gene Name

 Rgs7bp 

Gene Synonyms/Alias

 D13Bwg1146e; R7bp 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
225	ETMPLPLKNQDDSSL	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cypolasmic shuttling. May also act by controlling the proteolytic stability of R7 proteins, probably by protecting them from degradation. 

Sequence Annotation

 MOTIF 242 247 Nuclear localization signal.
 LIPID 252 252 S-palmitoyl cysteine (Probable).
 LIPID 253 253 S-palmitoyl cysteine (Probable).  

Keyword

 Cell membrane; Complete proteome; Cytoplasm; Lipoprotein; Membrane; Nucleus; Palmitate; Reference proteome; Signal transduction inhibitor. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 257 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0007186; P:G-protein coupled receptor signaling pathway; IDA:MGI.
 GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW. 

Interpro

 IPR026512; RGS7BP/RGS9BP. 

Pfam

  

SMART

  

PROSITE

  

PRINTS