UniProt Accession

 MMP20_MOUSE; P57748; A7MCV5 

Genbank Protein ID

 AF156956; AF156947; AF156948; AF156949; AF156950; AF156951; AF156952; AF156953; AF156954; AF156955; AF155933; BC152335; BC152336 

Genbank Nucleotide ID

 AAF28472.1; AAF28472.1; AAF28472.1; AAF28472.1; AAF28472.1; AAF28472.1; AAF28472.1; AAF28472.1; AAF28472.1; AAF28472.1; AAF28470.1; AAI52336.1; AAI52337.1 

Protein Name

 Matrix metalloproteinase-20 

Protein Synonyms/Alias

 MMP-20; Enamel metalloproteinase; Enamelysin 

Gene Name

 Mmp20 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
273	QALYGPRKIFPGKPT	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation (By similarity). 

Sequence Annotation

 REPEAT 292 342 Hemopexin 1.
 REPEAT 343 388 Hemopexin 2.
 REPEAT 390 438 Hemopexin 3.
 REPEAT 439 482 Hemopexin 4.
 MOTIF 97 104 Cysteine switch (By similarity).
 ACT_SITE 226 226 By similarity.
 METAL 99 99 Zinc 1; in inhibited form (By
 METAL 163 163 Calcium 1 (By similarity).
 METAL 164 164 Calcium 1; via carbonyl oxygen (By
 METAL 165 165 Calcium 1; via carbonyl oxygen (By
 METAL 175 175 Zinc 2 (By similarity).
 METAL 177 177 Zinc 2 (By similarity).
 METAL 182 182 Calcium 2 (By similarity).
 METAL 183 183 Calcium 2; via carbonyl oxygen (By
 METAL 185 185 Calcium 2; via carbonyl oxygen (By
 METAL 187 187 Calcium 2; via carbonyl oxygen (By
 METAL 190 190 Zinc 2 (By similarity).
 METAL 196 196 Calcium 1; via carbonyl oxygen (By
 METAL 197 197 Calcium 1; via carbonyl oxygen (By
 METAL 199 199 Calcium 1; via carbonyl oxygen (By
 METAL 201 201 Calcium 1 (By similarity).
 METAL 203 203 Zinc 2 (By similarity).
 METAL 205 205 Calcium 2 (By similarity).
 METAL 208 208 Calcium 2 (By similarity).
 METAL 225 225 Zinc 1; catalytic (By similarity).
 METAL 229 229 Zinc 1; catalytic (By similarity).
 METAL 235 235 Zinc 1; catalytic (By similarity).
 DISULFID 295 482 By similarity.  

Keyword

 Autocatalytic cleavage; Calcium; Complete proteome; Disulfide bond; Extracellular matrix; Hydrolase; Metal-binding; Metalloprotease; Protease; Reference proteome; Repeat; Secreted; Signal; Zinc; Zymogen. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 482 AA 

Protein Sequence

Gene Ontology

 GO:0005578; C:proteinaceous extracellular matrix; IEA:UniProtKB-SubCell.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0097186; P:amelogenesis; IMP:MGI.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 

Interpro

 IPR000585; Hemopexin-like_dom.
 IPR018487; Hemopexin-like_repeat.
 IPR024079; MetalloPept_cat_dom.
 IPR001818; Pept_M10_metallopeptidase.
 IPR021190; Pept_M10A.
 IPR016293; Pept_M10A_Metazoans.
 IPR021158; Pept_M10A_Zn_BS.
 IPR006026; Peptidase_Metallo.
 IPR002477; Peptidoglycan-bd-like. 

Pfam

 PF00045; Hemopexin
 PF00413; Peptidase_M10
 PF01471; PG_binding_1 

SMART

 SM00120; HX
 SM00235; ZnMc 

PROSITE

 PS00546; CYSTEINE_SWITCH
 PS00024; HEMOPEXIN
 PS51642; HEMOPEXIN_2
 PS00142; ZINC_PROTEASE 

PRINTS

 PR00138; MATRIXIN.