| Tag | Content |
|---|
| CPLM ID | CPLM-021596 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Pleckstrin homology domain-containing family A member 2 |
Protein Synonyms/Alias | PH domain-containing family A member 2; Tandem PH domain-containing protein 2; TAPP-2 |
Gene Name | PLEKHA2 |
Gene Synonyms/Alias | TAPP2 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 102 | ANDQKDMKDWVEALN | ubiquitination | [1] | | 113 | EALNQASKITVPKGG | ubiquitination | [1] | | 118 | ASKITVPKGGGLPMT | ubiquitination | [1] | | 130 | PMTTEVLKSLAAPPA | ubiquitination | [1] | | 140 | AAPPALEKKPQVAYK | ubiquitination | [1] | | 201 | STGPPLIKSGYCVKQ | ubiquitination | [1] | | 207 | IKSGYCVKQGNVRKS | ubiquitination | [1] | | 245 | PLRTIFLKDVLKTHE | ubiquitination | [1] | | 301 | GAAVQALKCHPRETS | ubiquitination | [1] | | 346 | EEKKALCKAPSVASS | ubiquitination | [1] | | 409 | EPQHPKEKPFMFNLD | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). |
Sequence Annotation | DOMAIN 7 113 PH 1.
DOMAIN 198 298 PH 2.
MOD_RES 182 182 Phosphoserine (By similarity).
MOD_RES 184 184 Phosphoserine.
MOD_RES 349 349 Phosphoserine. |
Keyword | Cell membrane; Complete proteome; Cytoplasm; Lipid-binding; Membrane; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 425 AA |
Protein Sequence | MPYVDRQNRI CGFLDIEEHE NSGKFLRRYF ILDTQANCLL WYMDNPQNLA MGAGAVGALQ 60
LTYISKVSIA TPKQKPKTPF CFVINALSQR YFLQANDQKD MKDWVEALNQ ASKITVPKGG 120
GLPMTTEVLK SLAAPPALEK KPQVAYKTEI IGGVVVHTPI SQNGGDGQEG SEPGSHTILR 180
RSQSYIPTSG CRASTGPPLI KSGYCVKQGN VRKSWKRRFF ALDDFTICYF KCEQDREPLR 240
TIFLKDVLKT HECLVKSGDL LMRDNLFEII TSSRTFYVQA DSPEDMHSWI KEIGAAVQAL 300
KCHPRETSFS RSISLTRPGS SSLSSGPNSI LCRGRPPLEE KKALCKAPSV ASSWQPWTPV 360
PQAGEKLLPP GDTSEDSLFT PRPGEGAPPG VLPSSRIRHR SEPQHPKEKP FMFNLDDENI 420
RTSDV 425 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:UniProtKB. GO:0016020; C:membrane; IDA:UniProtKB. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0043234; C:protein complex; IDA:UniProtKB. GO:0005545; F:1-phosphatidylinositol binding; IEA:Compara. GO:0001968; F:fibronectin binding; IMP:UniProtKB. GO:0043236; F:laminin binding; IMP:UniProtKB. GO:0001954; P:positive regulation of cell-matrix adhesion; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |