CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022761
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Metastasis-associated protein MTA2 
Protein Synonyms/Alias
 Metastasis-associated 1-like 1 
Gene Name
 Mta2 
Gene Synonyms/Alias
 Mta1l1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
71REFEEESKQPGVSEQubiquitination[1]
152GEIRVGCKFQAEIPDacetylation[2, 3]
152GEIRVGCKFQAEIPDubiquitination[1]
173SDNRNQQKMEMKVWDubiquitination[1]
460TFLLQTTKLTRLARRacetylation[3]
508KAAKTPLKIHPLVRLacetylation[2]
508KAAKTPLKIHPLVRLubiquitination[1]
522LPLATIVKDLVAQAPacetylation[3]
531LVAQAPLKPKTPRGTacetylation[3]
611PVVFVATKDTRALRKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins. 
Sequence Annotation
 DOMAIN 1 144 BAH.
 DOMAIN 145 256 ELM2.
 DOMAIN 263 315 SANT.
 ZN_FING 367 394 GATA-type; atypical.
 MOD_RES 152 152 N6-acetyllysine (By similarity).
 MOD_RES 433 433 Phosphoserine (By similarity).
 MOD_RES 435 435 Phosphoserine (By similarity).
 MOD_RES 534 534 Phosphothreonine (By similarity).  
Keyword
 Acetylation; Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 668 AA 
Protein Sequence
MAANMYRVGD YVYFENSSSN PYLVRRIEEL NKTANGNVEA KVVCLFRRRD ISSSLNSLAD 60
SNAREFEEES KQPGVSEQQR HQLKHRELFL SRQFESLPAT HIRGKCSVTL LNETDILNQY 120
LDKEDCFFYS LVFDPVQKTL LADQGEIRVG CKFQAEIPDR LAEGESDNRN QQKMEMKVWD 180
PDNPLTDRQI DQFLVVARAV GTFARALDCS SSIRQPSLHM SAAAASRDIT LFHAMDTLQR 240
NGYDLAKAMS TLVPQGGPVL CRDEMEEWSA SEAMLFEEAL EKYGKDFNDI RQDFLPWKSL 300
ASIVQFYYMW KTTDRYIQQK RLKAAEADSK LKQVYIPTYT KPNPNQIISV GSKPGMNGAG 360
FQKGLTCESC HTTQSAQWYA WGPPNMQCRL CASCWIYWKK YGGLKTPTQL EGAARGTTEP 420
HSRGHLSRPE AQSLSPYTTS ANRAKLLAKN RQTFLLQTTK LTRLARRMCR DLLQPRRAAR 480
RPYAPINANA IKAECSIRLP KAAKTPLKIH PLVRLPLATI VKDLVAQAPL KPKTPRGTKT 540
PINRNQLTQN RGLGGIMVKR SYETMAGAGV PFSANGRPLA SGIRSSSQPA AKRQKLNPAD 600
APNPVVFVAT KDTRALRKAL THLEMRRAAR RPNLPLKVKP TLMTVRPPVP LPASSHPAST 660
NEPIVLED 668 
Gene Ontology
 GO:0016581; C:NuRD complex; IDA:MGI.
 GO:0005667; C:transcription factor complex; IEA:Compara.
 GO:0003682; F:chromatin binding; IEA:InterPro.
 GO:0004407; F:histone deacetylase activity; IDA:MGI.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0000989; F:transcription factor binding transcription factor activity; IDA:UniProtKB.
 GO:0044212; F:transcription regulatory region DNA binding; IDA:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006338; P:chromatin remodeling; TAS:MGI.
 GO:0006306; P:DNA methylation; IMP:MGI.
 GO:0006323; P:DNA packaging; TAS:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI. 
Interpro
 IPR001025; BAH_dom.
 IPR000949; ELM2_dom.
 IPR009057; Homeodomain-like.
 IPR001005; SANT/Myb.
 IPR017884; SANT_dom.
 IPR000679; Znf_GATA. 
Pfam
 PF01426; BAH
 PF01448; ELM2
 PF00320; GATA 
SMART
 SM00439; BAH
 SM00717; SANT
 SM00401; ZnF_GATA 
PROSITE
 PS51038; BAH
 PS51156; ELM2
 PS00344; GATA_ZN_FINGER_1
 PS50114; GATA_ZN_FINGER_2
 PS51293; SANT 
PRINTS