CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005248
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glycerol uptake/efflux facilitator protein 
Protein Synonyms/Alias
  
Gene Name
 FPS1 
Gene Synonyms/Alias
 YLL043W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
221RNVPIMVKPKTLYQNubiquitination[1]
593GERMALQKTKTKSSIubiquitination[1]
597ALQKTKTKSSISDNEubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Channel protein for glycerol. Has a role in both glycerol influx and efflux. Plays a role in osmoregulation: under osmotic stress the channel is apparently closed to allow accumulation of glycerol in the cell under hyperosmotic conditions. 
Sequence Annotation
 MOTIF 352 354 NPA 1.
 MOTIF 480 482 NPA 2.
 MOD_RES 150 150 Phosphoserine.
 MOD_RES 168 168 Phosphothreonine.
 MOD_RES 209 209 Phosphoserine.
 MOD_RES 212 212 Phosphoserine.  
Keyword
 Complete proteome; Glycerol metabolism; Membrane; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 669 AA 
Protein Sequence
MSNPQKALND FLSSESVHTH DSSRKQSNKQ SSDEGRSSSQ PSHHHSGGTN NNNNNNNNNN 60
NSNNNNNGND GGNDDDYDYE MQDYRPSPQS ARPTPTYVPQ YSVESGTAFP IQEVIPSAYI 120
NTQDINHKDN GPPSASSNRA FRPRGQTTVS ANVLNIEDFY KNADDAHTIP ESHLSRRRSR 180
SRATSNAGHS ANTGATNGRT TGAQTNMESN ESPRNVPIMV KPKTLYQNPQ TPTVLPSTYH 240
PINKWSSVKN TYLKEFLAEF MGTMVMIIFG SAVVCQVNVA GKIQQDNFNV ALDNLNVTGS 300
SAETIDAMKS LTSLVSSVAG GTFDDVALGW AAAVVMGYFC AGGSAISGAH LNPSITLANL 360
VYRGFPLKKV PYYFAGQLIG AFTGALILFI WYKRVLQEAY SDWWMNESVA GMFCVFPKPY 420
LSSGRQFFSE FLCGAMLQAG TFALTDPYTC LSSDVFPLMM FILIFIINAS MAYQTGTAMN 480
LARDLGPRLA LYAVGFDHKM LWVHHHHFFW VPMVGPFIGA LMGGLVYDVC IYQGHESPVN 540
WSLPVYKEMI MRAWFRRPGW KKRNRARRTS DLSDFSYNND DDEEFGERMA LQKTKTKSSI 600
SDNENEAGEK KVQFKSVQRG KRTFGGIPTI LEEEDSIETA SLGATTTDSI GLSDTSSEDS 660
HYGNAKKVT 669 
Gene Ontology
 GO:0000324; C:fungal-type vacuole; IDA:SGD.
 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0005886; C:plasma membrane; IDA:SGD.
 GO:0015254; F:glycerol channel activity; IMP:SGD.
 GO:0006846; P:acetate transport; IMP:SGD.
 GO:0015700; P:arsenite transport; IMP:SGD.
 GO:0000747; P:conjugation with cellular fusion; IMP:SGD.
 GO:0006071; P:glycerol metabolic process; IEA:UniProtKB-KW.
 GO:0046685; P:response to arsenic-containing substance; IMP:SGD. 
Interpro
 IPR023271; Aquaporin-like.
 IPR000425; MIP.
 IPR022357; MIP_CS. 
Pfam
 PF00230; MIP 
SMART
  
PROSITE
 PS00221; MIP 
PRINTS
 PR00783; MINTRINSICP.