CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039969
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Interferon gamma receptor 1 
Protein Synonyms/Alias
  
Gene Name
 IFNGR1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
251KINPLKEKSIILPKSubiquitination[1, 2]
257EKSIILPKSLISVVRubiquitination[1, 2, 3, 4, 5, 6, 7, 8]
271RSATLETKPESKYVSubiquitination[2, 4, 7, 8]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [6] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [7] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [8] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 461 AA 
Protein Sequence
MPTPTNVTIE SYNMNPIVYW EYQIMPQVPV FTVEVKNYGV KNSEWIDACI NISHHYCNIS 60
DHVGDPSNSL WVRVKARVGQ KESAYAKSEE FAVCRDGKIG PPKLDIRKEE KQIMIDIFHP 120
SVFVNGDEQE VDYDPETTCY IRVYNVYVRM NGSEIQYKIL TQKEDDCDEI QCQLAIPVSS 180
LNSQYCVSAE GVLHVWGVTT EKSKEVCITI FNSSIKGSLW IPVVAALLLF LVLSLVFICF 240
YIKKINPLKE KSIILPKSLI SVVRSATLET KPESKYVSLI TSYQPFSLEK EVVCEEPLSP 300
ATVPGMHTED NPGKVEHTEE LSSITEVVTT EENIPDVVPG SHLTPIERES SSPLSSNQSE 360
PGSIALNSYH SRNCSESDHS RNGFDTDSSC LESHSSLSDS EFPPNNKGEI KTEGQELITV 420
IKAPTSFGYD KPHVLVDLLV DDSGKESLIG YRPTEDSKEF S 461 
Gene Ontology
 GO:0016020; C:membrane; IEA:InterPro. 
Interpro
 IPR003961; Fibronectin_type3.
 IPR013783; Ig-like_fold.
 IPR021126; Interferon_gamma_pox/mammal.
 IPR008355; Interferon_gamma_rcpt_asu. 
Pfam
 PF07140; IFNGR1 
SMART
  
PROSITE
  
PRINTS
 PR01777; INTERFERONGR.