CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016896
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Carbonic anhydrase 12 
Protein Synonyms/Alias
 Carbonate dehydratase XII; Carbonic anhydrase XII; CA-XII 
Gene Name
 Ca12 
Gene Synonyms/Alias
 Car12 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
343DNKGVIYKPAIKKEAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Reversible hydration of carbon dioxide. 
Sequence Annotation
 REGION 227 228 Substrate binding (By similarity).
 ACT_SITE 94 94 Proton acceptor (By similarity).
 ACT_SITE 155 155 By similarity.
 METAL 120 120 Zinc; catalytic.
 METAL 122 122 Zinc; catalytic.
 METAL 146 146 Zinc; catalytic.
 CARBOHYD 28 28 N-linked (GlcNAc...) (Potential).
 CARBOHYD 42 42 N-linked (GlcNAc...) (Potential).
 CARBOHYD 80 80 N-linked (GlcNAc...) (Potential).
 CARBOHYD 88 88 N-linked (GlcNAc...) (Potential).
 DISULFID 50 231 By similarity.  
Keyword
 Complete proteome; Disulfide bond; Glycoprotein; Lyase; Membrane; Metal-binding; Reference proteome; Signal; Transmembrane; Transmembrane helix; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 354 AA 
Protein Sequence
MPHRSLRATV VLLLVILKKQ PSSSAPLNGS KWTYVGPAGE KNWSKKYPSC GGLLQSPIDL 60
HSDILQYDAS LAPLQFQGYN VSVEKLLNLT NDGHSVRLNL NSDMYIQGLQ PHHYRAEQLH 120
LHWGNRNDPH GSEHTVSGKH FAAELHIVHY NSDLYPDFST ASDKSEGLAV LAVLIEIGSA 180
NPSYDKIFSH LQHVKYKGQQ VLIPGFNIEE LLPESPGEYY RYEGSLTTPP CYPTVLWTVF 240
RNPVQISQEQ LLALETALYF THMDDPTPRE MINNFRQVQK FDERLVYISF RQGLLTDTGL 300
SLGIILSVAL AGVLGISIVL AVSIWLFKRK KSKKGDNKGV IYKPAIKKEA EVHA 354 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0004089; F:carbonate dehydratase activity; IEA:EC.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006730; P:one-carbon metabolic process; IEA:InterPro. 
Interpro
 IPR001148; Carbonic_anhydrase_a.
 IPR023561; Carbonic_anhydrase_a-class.
 IPR018338; Carbonic_anhydrase_a-class_CS.
 IPR018430; Carbonic_anhydrase_CA12. 
Pfam
 PF00194; Carb_anhydrase 
SMART
 SM01057; Carb_anhydrase 
PROSITE
 PS00162; ALPHA_CA_1
 PS51144; ALPHA_CA_2 
PRINTS