| Tag | Content |
|---|
| CPLM ID | CPLM-024739 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein-glutamine gamma-glutamyltransferase E |
Protein Synonyms/Alias | Transglutaminase E; TG(E); TGE; TGase E; Transglutaminase-3; TGase-3; Protein-glutamine gamma-glutamyltransferase E 50 kDa catalytic chain; Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain |
Gene Name | Tgm3 |
Gene Synonyms/Alias | Tgase3 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 71 | PSESARTKAVFSISG | acetylation | [1] | | 421 | VDTYSIGKYISTKAV | acetylation | [1] | | 486 | KEPSISGKFKVTGVL | acetylation | [1] | | 565 | SQYDRYLKADNMIRI | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold. In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath (By similarity). |
Sequence Annotation | ACT_SITE 273 273 By similarity.
ACT_SITE 331 331 By similarity.
ACT_SITE 354 354 By similarity.
METAL 394 394 Calcium (By similarity).
METAL 396 396 Calcium (By similarity).
METAL 444 444 Calcium (By similarity).
METAL 449 449 Calcium (By similarity).
MOD_RES 111 111 Phosphotyrosine (By similarity).
MOD_RES 112 112 Phosphothreonine (By similarity). |
Keyword | Acyltransferase; Calcium; Complete proteome; Keratinization; Metal-binding; Phosphoprotein; Reference proteome; Transferase; Zymogen. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 693 AA |
Protein Sequence | MSALEVQNIN WQMPMNRRAH HTDKFSSQDF IVRRGQPWEV ILLCNRSLES GDNLNFIVST 60
GPQPSESART KAVFSISGRN TSGWSAALKA SNGNNLFIAI ASPVSAPIGL YTLNVEVSSK 120
GRVSSVKLGT FTVLFNPWQQ GDDVFMSNHA ERQEYVEEDS GIIYVGSTNR IGMVGWNFGQ 180
FEEDILSISL SILDRSLNFR RDPATDVARR NDPKYVCRVL SAMINANDDS GVLSGNWSGN 240
YSGGVDPRTW NGSVEILKNW KKSGFRPVQF GQCWVFAGTL NTVLRCLGVP SRVITNFNSA 300
HDTDRNLSVD VYYDAMGNPL EKGSDSVWNF HVWNEGWFVR TDLGPSYNGW QVLDATPQER 360
SQGVFQCGPA SVNAIKDGEV DQNFDMIFIF AEVNADRITW IYNNRDGSQK QNSVDTYSIG 420
KYISTKAVGS NSRMDVTIKY KHPEGSKEER QVQQKAMNKL KPNASFGATS SRGPQGEEKE 480
PSISGKFKVT GVLAVGKEVS LALILKNTTS DRKTVTTNMT AWTIVYNGTL VHEVWKDSAT 540
ISLDPEEEIQ YPVKIAYSQY DRYLKADNMI RITAVCKVPD EAEVVVERDV ILDNPTLTLE 600
VLDQAQLRKP VVVQMLFSNP LDEPVKNCVL MVEGSGLLRG SLKIDVPALR PKEKSRVRFE 660
IFPTRIGIKQ LLADFSCNKF PAIKAMLVIE VSE 693 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:Compara. GO:0031234; C:extrinsic to internal side of plasma membrane; IEA:Compara. GO:0005509; F:calcium ion binding; IEA:Compara. GO:0019003; F:GDP binding; IEA:Compara. GO:0005525; F:GTP binding; IEA:Compara. GO:0003924; F:GTPase activity; IEA:Compara. GO:0000287; F:magnesium ion binding; IEA:Compara. GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IEA:EC. GO:0043163; P:cell envelope organization; IEA:Compara. GO:0031424; P:keratinization; IEA:UniProtKB-KW. GO:0018149; P:peptide cross-linking; IEA:Compara. GO:0051262; P:protein tetramerization; IEA:Compara. |
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