UniProt Accession

 TPM1_MOUSE; P58771; P02558; P19354; P46902; P99034 

Genbank Protein ID

 X64831; M22479 

Genbank Nucleotide ID

 CAA46043.1; AAA40483.1 

Protein Name

 Tropomyosin alpha-1 chain 

Protein Synonyms/Alias

 Alpha-tropomyosin; Tropomyosin-1 

Gene Name

 Tpm1 

Gene Synonyms/Alias

 Tpm-1; Tpma 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
7	*MDAIKKKMQMLKLD	ubiquitination	[1]
12	KKKMQMLKLDKENAL	ubiquitination	[1]
15	MQMLKLDKENALDRA	ubiquitination	[1]
29	AEQAEADKKAAEDRS	ubiquitination	[1]
30	EQAEADKKAAEDRSK	ubiquitination	[1]
37	KAAEDRSKQLEDELV	ubiquitination	[1]
48	DELVSLQKKLKGTED	ubiquitination	[1]
49	ELVSLQKKLKGTEDE	ubiquitination	[1]
51	VSLQKKLKGTEDELD	ubiquitination	[1]
59	GTEDELDKYSEALKD	ubiquitination	[1]
65	DKYSEALKDAQEKLE	ubiquitination	[1]
70	ALKDAQEKLELAEKK	ubiquitination	[1]
76	EKLELAEKKATDAEA	ubiquitination	[1]
77	KLELAEKKATDAEAD	ubiquitination	[1, 2]
112	RLATALQKLEEAEKA	ubiquitination	[1]
118	QKLEEAEKAADESER	ubiquitination	[1]
128	DESERGMKVIESRAQ	ubiquitination	[1]
136	VIESRAQKDEEKMEI	ubiquitination	[1]
140	RAQKDEEKMEIQEIQ	ubiquitination	[1]
149	EIQEIQLKEAKHIAE	ubiquitination	[1]
152	EIQLKEAKHIAEDAD	ubiquitination	[1]
161	IAEDADRKYEEVARK	ubiquitination	[1]
168	KYEEVARKLVIIESD	ubiquitination	[1]
189	RAELSEGKCAELEEE	ubiquitination	[1]
198	AELEEELKTVTNNLK	ubiquitination	[1]
205	KTVTNNLKSLEAQAE	ubiquitination	[1]
213	SLEAQAEKYSQKEDK	ubiquitination	[1]
217	QAEKYSQKEDKYEEE	ubiquitination	[1]
220	KYSQKEDKYEEEIKV	ubiquitination	[1]
226	DKYEEEIKVLSDKLK	ubiquitination	[1]
231	EIKVLSDKLKEAETR	ubiquitination	[1]
233	KVLSDKLKEAETRAE	ubiquitination	[1]
248	FAERSVTKLEKSIDD	ubiquitination	[1]
251	RSVTKLEKSIDDLED	ubiquitination	[1]
264	EDELYAQKLKYKAIS	ubiquitination	[1]
266	ELYAQKLKYKAISEE	ubiquitination	[1]
268	YAQKLKYKAISEELD	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] A proteomics approach to identify the ubiquitinated proteins in mouse heart.
 Jeon HB, Choi ES, Yoon JH, Hwang JH, Chang JW, Lee EK, Choi HW, Park ZY, Yoo YJ.
 Biochem Biophys Res Commun. 2007 Jun 8;357(3):731-6. [PMID: 17451654] 

Functional Description

 Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 283 283 Phosphoserine; alternate.
 MOD_RES 283 283 Phosphoserine; by DAPK1; alternate (By
 CROSSLNK 77 77 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Acetylation; Actin-binding; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Isopeptide bond; Muscle protein; Phosphoprotein; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 284 AA 

Protein Sequence

Gene Ontology

 GO:0032059; C:bleb; IEA:Compara.
 GO:0005862; C:muscle thin filament tropomyosin; TAS:MGI.
 GO:0032587; C:ruffle membrane; IEA:Compara.
 GO:0001725; C:stress fiber; IEA:Compara.
 GO:0005200; F:structural constituent of cytoskeleton; TAS:MGI.
 GO:0060048; P:cardiac muscle contraction; IMP:BHF-UCL.
 GO:0034614; P:cellular response to reactive oxygen species; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0030049; P:muscle filament sliding; IEA:Compara.
 GO:0030336; P:negative regulation of cell migration; IEA:Compara.
 GO:0032781; P:positive regulation of ATPase activity; IEA:Compara.
 GO:0045785; P:positive regulation of cell adhesion; IEA:Compara.
 GO:0003065; P:positive regulation of heart rate by epinephrine; IMP:BHF-UCL.
 GO:0051496; P:positive regulation of stress fiber assembly; IEA:Compara.
 GO:0031529; P:ruffle organization; IEA:Compara.
 GO:0045214; P:sarcomere organization; IEA:Compara.
 GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IMP:BHF-UCL.
 GO:0042060; P:wound healing; IEA:Compara. 

Interpro

 IPR000533; Tropomyosin. 

Pfam

 PF00261; Tropomyosin 

SMART

  

PROSITE

 PS00326; TROPOMYOSIN 

PRINTS

 PR00194; TROPOMYOSIN.