| Tag | Content |
|---|
| CPLM ID | CPLM-013780 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Rab-interacting lysosomal protein |
Protein Synonyms/Alias | |
Gene Name | Rilp |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 238 | LQERNELKANVFLLK | ubiquitination | [1] | | 245 | KANVFLLKEELAYFQ | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Rab effector playing a role in late endocytic transport to degradative compartments. Involved in the regulation of lysosomal morphology and distribution. Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments. Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes (By similarity). |
Sequence Annotation | DOMAIN 215 249 RILP-like.
REGION 251 312 Necessary for the interaction with RAB7A
MOD_RES 193 193 Phosphoserine.
MOD_RES 293 293 Phosphoserine (By similarity).
MOD_RES 294 294 Phosphoserine (By similarity). |
Keyword | Coiled coil; Complete proteome; Cytoplasmic vesicle; Endosome; Lysosome; Membrane; Phosphoprotein; Protein transport; Reference proteome; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 369 AA |
Protein Sequence | MEPRRAAPRL PSQASSSVGA GSAAELVYHL AGALGTELQG LARRFGPDAA AGLVPLVVRA 60
LELLEKAAVG PAPDSLQVSA QQAEVELRRL REENQRLRQE LGSGPQEERA LLRQLKEVTD 120
RQRDELRAHN RDLQRRSQET EALQEQLQRL LLINSELRHK LAAVQTQLRA AQDRERERQI 180
AQDGSSQLAK EQSLEPDAAT SDDPVDTQKQ PGNLPEAVQC GFSREELKQI LQERNELKAN 240
VFLLKEELAY FQRELLTDHR VPGLLLEAMK VAVKKQRRKI KAKMLGTPEE AESSEDEDGS 300
WLLLSNDKED VPLVPESRIQ NFFGLWYRGE TEAPEAETSN PASSSLQKGE ETPQQPHLQP 360
VNSPPAPNS 369 |
Gene Ontology | GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell. GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell. GO:0005739; C:mitochondrion; IDA:MGI. GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell. GO:0008333; P:endosome to lysosome transport; IEA:Compara. GO:0015031; P:protein transport; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |