CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011838
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein EMP46 
Protein Synonyms/Alias
 46 kDa endomembrane protein 
Gene Name
 EMP46 
Gene Synonyms/Alias
 YLR080W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
183AYLNDGTKDLDIESSubiquitination[1]
Reference
 [1] Identification, analysis, and prediction of protein ubiquitination sites.
 Radivojac P, Vacic V, Haynes C, Cocklin RR, Mohan A, Heyen JW, Goebl MG, Iakoucheva LM.
 Proteins. 2010 Feb 1;78(2):365-80. [PMID: 19722269] 
Functional Description
 Involved in the secretion of glycoproteins and in nucleus architecture and gene silencing. 
Sequence Annotation
 DOMAIN 52 269 L-type lectin-like.
 REGION 429 432 Mediates the interactions with COPI and
 MOTIF 440 444 Di-lysine motif.
 METAL 177 177 Potassium.
 DISULFID 196 230  
Keyword
 3D-structure; Complete proteome; Direct protein sequencing; Disulfide bond; Endoplasmic reticulum; Golgi apparatus; Lectin; Membrane; Metal-binding; Potassium; Protein transport; Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 444 AA 
Protein Sequence
MTTRKTASSL QLLGKITGTK AGTKQKKMNF INGLIWLYMC VWMVHGKVTQ KDELKWNKGY 60
SLPNLLEVTD QQKELSQWTL GDKVKLEEGR FVLTPGKNTK GSLWLKPEYS IKDAMTIEWT 120
FRSFGFRGST KGGLAFWLKQ GNEGDSTELF GGSSKKFNGL MILLRLDDKL GESVTAYLND 180
GTKDLDIESS PYFASCLFQY QDSMVPSTLR LTYNPLDNHL LKLQMDNRVC FQTRKVKFMG 240
SSPFRIGTSA INDASKESFE ILKMKLYDGV IEDSLIPNVN PMGQPRVVTK VINSQTGEES 300
FREKMPFSDK EESITSNELF EKMNKLEGKI MANDIDPLLR KMNKIVENER ELIQRLRPLL 360
DLKKTAISDD SFQDFLSMNA NLDRLIKEQE KIRQDAKLYG KQTKGHDEIF SKISVWLALL 420
IFIMITLAYY MFRINQDIKK VKLL 444 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0030134; C:ER to Golgi transport vesicle; IPI:SGD.
 GO:0000139; C:Golgi membrane; IDA:SGD.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0001948; F:glycoprotein binding; IDA:SGD.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006888; P:ER to Golgi vesicle-mediated transport; IGI:SGD.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 
Interpro
 IPR008985; ConA-like_lec_gl_sf.
 IPR013320; ConA-like_subgrp.
 IPR016710; L-typ_lectin_fun.
 IPR005052; Lectin_leg. 
Pfam
 PF03388; Lectin_leg-like 
SMART
  
PROSITE
 PS51328; L_LECTIN_LIKE 
PRINTS