CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008557
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Aldo-keto reductase family 1 member C2 
Protein Synonyms/Alias
 3-alpha-HSD3; Chlordecone reductase homolog HAKRD; Dihydrodiol dehydrogenase 2; DD-2; DD2; Dihydrodiol dehydrogenase/bile acid-binding protein; DD/BABP; Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Type III 3-alpha-hydroxysteroid dehydrogenase 
Gene Name
 AKR1C2 
Gene Synonyms/Alias
 DDH2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
4****MDSKYQCVKLNacetylation[1]
31YAPAEVPKSKALEAVacetylation[1]
161CKDAGLAKSIGVSNFacetylation[1]
179LLEMILNKPGLKYKPacetylation[1]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 
Functional Description
 Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha- DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability. 
Sequence Annotation
 NP_BIND 216 280 NADP.
 ACT_SITE 55 55 Proton donor.
 BINDING 117 117 Substrate.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Lipid metabolism; NADP; Oxidoreductase; Polymorphism; Reference proteome; Steroid metabolism. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 323 AA 
Protein Sequence
MDSKYQCVKL NDGHFMPVLG FGTYAPAEVP KSKALEAVKL AIEAGFHHID SAHVYNNEEQ 60
VGLAIRSKIA DGSVKREDIF YTSKLWSNSH RPELVRPALE RSLKNLQLDY VDLYLIHFPV 120
SVKPGEEVIP KDENGKILFD TVDLCATWEA MEKCKDAGLA KSIGVSNFNH RLLEMILNKP 180
GLKYKPVCNQ VECHPYFNQR KLLDFCKSKD IVLVAYSALG SHREEPWVDP NSPVLLEDPV 240
LCALAKKHKR TPALIALRYQ LQRGVVVLAK SYNEQRIRQN VQVFEFQLTS EEMKAIDGLN 300
RNVRYLTLDI FAGPPNYPFS DEY 323 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004032; F:alditol:NADP+ 1-oxidoreductase activity; IDA:UniProtKB.
 GO:0047026; F:androsterone dehydrogenase (A-specific) activity; IEA:EC.
 GO:0032052; F:bile acid binding; IDA:UniProtKB.
 GO:0047086; F:ketosteroid monooxygenase activity; IDA:UniProtKB.
 GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; IDA:UniProtKB.
 GO:0018636; F:phenanthrene 9,10-monooxygenase activity; IDA:UniProtKB.
 GO:0004958; F:prostaglandin F receptor activity; IDA:UniProtKB.
 GO:0047115; F:trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity; IDA:UniProtKB.
 GO:0071395; P:cellular response to jasmonic acid stimulus; IDA:UniProtKB.
 GO:0044597; P:daunorubicin metabolic process; IMP:UniProtKB.
 GO:0007586; P:digestion; IDA:UniProtKB.
 GO:0044598; P:doxorubicin metabolic process; IMP:UniProtKB.
 GO:0008284; P:positive regulation of cell proliferation; IDA:UniProtKB.
 GO:0051897; P:positive regulation of protein kinase B signaling cascade; IDA:UniProtKB.
 GO:0042448; P:progesterone metabolic process; IDA:UniProtKB.
 GO:0006693; P:prostaglandin metabolic process; IDA:UniProtKB.
 GO:0034694; P:response to prostaglandin stimulus; IDA:UniProtKB. 
Interpro
 IPR001395; Aldo/ket_red.
 IPR018170; Aldo/ket_reductase_CS.
 IPR020471; Aldo/keto_reductase_subgr.
 IPR023210; NADP_OxRdtase_dom. 
Pfam
 PF00248; Aldo_ket_red 
SMART
  
PROSITE
 PS00798; ALDOKETO_REDUCTASE_1
 PS00062; ALDOKETO_REDUCTASE_2
 PS00063; ALDOKETO_REDUCTASE_3 
PRINTS
 PR00069; ALDKETRDTASE.