CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019097
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Modulator of apoptosis 1 
Protein Synonyms/Alias
 MAP-1; MAP1; Paraneoplastic antigen Ma4 
Gene Name
 MOAP1 
Gene Synonyms/Alias
 PNMA4 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
63FRRDENRKVALVGLTubiquitination[1]
85VPKEIPGKGGIWRVIubiquitination[1, 2, 3]
94GIWRVIFKPPDPDNTubiquitination[1, 2]
193FHTTQMIKAWQVPDVubiquitination[2]
202WQVPDVEKRRRLLESubiquitination[1, 2]
253NPRELQVKYLTTYQKubiquitination[1, 2, 3, 4]
260KYLTTYQKDEEKLSAubiquitination[1, 2, 3]
264TYQKDEEKLSAYVLRubiquitination[1]
278RLEPLLQKLVQRGAIubiquitination[1, 2, 3, 4]
305VIAGAVHKTIRRELNubiquitination[1, 2, 3, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. 
Sequence Annotation
 REGION 120 127 BH3-like.
 REGION 202 205 RASSF1-binding.  
Keyword
 Apoptosis; Complete proteome; Reference proteome; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 351 AA 
Protein Sequence
MTLRLLEDWC RGMDMNPRKA LLIAGISQSC SVAEIEEALQ AGLAPLGEYR LLGRMFRRDE 60
NRKVALVGLT AETSHALVPK EIPGKGGIWR VIFKPPDPDN TFLSRLNEFL AGEGMTVGEL 120
SRALGHENGS LDPEQGMIPE MWAPMLAQAL EALQPALQCL KYKKLRVFSG RESPEPGEEE 180
FGRWMFHTTQ MIKAWQVPDV EKRRRLLESL RGPALDVIRV LKINNPLITV DECLQALEEV 240
FGVTDNPREL QVKYLTTYQK DEEKLSAYVL RLEPLLQKLV QRGAIERDAV NQARLDQVIA 300
GAVHKTIRRE LNLPEDGPAP GFLQLLVLIK DYEAAEEEEA LLQAILEGNF T 351 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:LIFEdb.
 GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:BHF-UCL.
 GO:0030262; P:apoptotic nuclear changes; IDA:BHF-UCL. 
Interpro
 IPR026523; PNMA.
 IPR026528; PNMA1/MOAP1. 
Pfam
  
SMART
  
PROSITE
  
PRINTS