UniProt Accession

 NUDE_ECOLI; P45799; Q2M762 

Genbank Protein ID

 U18997; U00096; AP009048 

Genbank Nucleotide ID

 AAA58194.1; AAC76422.1; BAE77894.1 

Protein Name

 ADP compounds hydrolase NudE 

Protein Synonyms/Alias

  

Gene Name

 nudE 

Gene Synonyms/Alias

 yrfE; b3397; JW3360 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
7	*MSKSLQKPTILNVE	acetylation	[1]
111	ANDLTFLKKLSMAPS	acetylation	[1]
181	FLVREWLKGQGRV**	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Active on adenosine(5')triphospho(5')adenosine (Ap3A), ADP-ribose, NADH, adenosine(5')diphospho(5')adenosine (Ap2A). 

Sequence Annotation

 DOMAIN 45 172 Nudix hydrolase.
 MOTIF 80 101 Nudix box.
 METAL 95 95 Divalent metal cation (By similarity).
 METAL 99 99 Divalent metal cation (By similarity).
 BINDING 40 40 Substrate; via amide nitrogen and
 BINDING 118 118 Substrate; via carbonyl oxygen.  

Keyword

 3D-structure; Complete proteome; Hydrolase; Magnesium; Metal-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 186 AA 

Protein Sequence

Gene Ontology

 GO:0019144; F:ADP-sugar diphosphatase activity; IDA:EcoCyc.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. 

Interpro

 IPR020084; NUDIX_hydrolase_CS.
 IPR000086; NUDIX_hydrolase_dom.
 IPR015797; NUDIX_hydrolase_dom-like. 

Pfam

 PF00293; NUDIX 

SMART

  

PROSITE

 PS51462; NUDIX
 PS00893; NUDIX_BOX 

PRINTS