CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004376
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 T-cell surface glycoprotein CD1e, membrane-associated 
Protein Synonyms/Alias
 hCD1e; R2G1; CD1e; T-cell surface glycoprotein CD1e, soluble; sCD1e 
Gene Name
 CD1E 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
78LGTIRFLKPWSHGNFubiquitination[1]
170IRAQNICKVLNRYLDubiquitination[1]
179LNRYLDIKEILQSLLubiquitination[1]
206EAGESELKRKVKPEAubiquitination[1]
208GESELKRKVKPEAWLubiquitination[1]
210SELKRKVKPEAWLSCubiquitination[1]
336LKKQSSNKNILSPHTubiquitination[1]
358GANTQDTKNSRHQFCubiquitination[1, 2]
373LAQVSWIKNRVLKKWubiquitination[1, 2, 3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724
Functional Description
 T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane- associated form is not active. 
Sequence Annotation
 DOMAIN 191 301 Ig-like.
 CARBOHYD 47 47 N-linked (GlcNAc...) (Potential).
 CARBOHYD 84 84 N-linked (GlcNAc...) (Potential).
 DISULFID 230 285 By similarity.  
Keyword
 3D-structure; Adaptive immunity; Alternative splicing; Complete proteome; Disulfide bond; Endosome; Glycoprotein; Golgi apparatus; Immunity; Immunoglobulin domain; Lipid-binding; Lysosome; Membrane; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 388 AA 
Protein Sequence
MLLLFLLFEG LCCPGENTAA PQALQSYHLA AEEQLSFRML QTSSFANHSW AHSEGSGWLG 60
DLQTHGWDTV LGTIRFLKPW SHGNFSKQEL KNLQSLFQLY FHSFIQIVQA SAGQFQLEYP 120
FEIQILAGCR MNAPQIFLNM AYQGSDFLSF QGISWEPSPG AGIRAQNICK VLNRYLDIKE 180
ILQSLLGHTC PRFLAGLMEA GESELKRKVK PEAWLSCGPS PGPGRLQLVC HVSGFYPKPV 240
WVMWMRGEQE QRGTQRGDVL PNADETWYLR ATLDVAAGEA AGLSCRVKHS SLGGHDLIIH 300
WGGYSIFLIL ICLTVIVTLV ILVVVDSRLK KQSSNKNILS PHTPSPVFLM GANTQDTKNS 360
RHQFCLAQVS WIKNRVLKKW KTRLNQLW 388 
Gene Ontology
 GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.
 GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
 GO:0043202; C:lysosomal lumen; IEA:UniProtKB-SubCell.
 GO:0019882; P:antigen processing and presentation; IEA:InterPro.
 GO:0006955; P:immune response; NAS:UniProtKB. 
Interpro
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003597; Ig_C1-set.
 IPR011161; MHC_I-like_Ag-recog.
 IPR011162; MHC_I/II-like_Ag-recog. 
Pfam
 PF07654; C1-set 
SMART
 SM00407; IGc1 
PROSITE
 PS50835; IG_LIKE 
PRINTS