UniProt Accession

 TNA1_YEAST; P53322; D6VV39 

Genbank Protein ID

 Y07777; Z73044; BK006941 

Genbank Nucleotide ID

 CAA69082.1; CAA97289.1; DAA08350.1 

Protein Name

 High-affinity nicotinic acid transporter 

Protein Synonyms/Alias

 Nicotinic acid permease 

Gene Name

 TNA1 

Gene Synonyms/Alias

 YGR260W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
54	HNRSHDKKSELATER	ubiquitination	[1]
283	EDSWFFNKEEKEYIS	ubiquitination	[2, 3, 4]
531	SDKNPEFKYMY****	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] A proteomics approach to understanding protein ubiquitination.
 Peng J, Schwartz D, Elias JE, Thoreen CC, Cheng D, Marsischky G, Roelofs J, Finley D, Gygi SP.
 Nat Biotechnol. 2003 Aug;21(8):921-6. [PMID: 12872131]
 [3] Computational identification of ubiquitylation sites from protein sequences.
 Tung CW, Ho SY.
 BMC Bioinformatics. 2008 Jul 15;9:310. [PMID: 18625080]
 [4] Identification, analysis, and prediction of protein ubiquitination sites.
 Radivojac P, Vacic V, Haynes C, Cocklin RR, Mohan A, Heyen JW, Goebl MG, Iakoucheva LM.
 Proteins. 2010 Feb 1;78(2):365-80. [PMID: 19722269] 

Functional Description

 Involved in the uptake of nicotinic acid. 

Sequence Annotation

 MOD_RES 27 27 Phosphoserine.
 CROSSLNK 283 283 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Complete proteome; Isopeptide bond; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Transport; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 534 AA 

Protein Sequence

Gene Ontology

 GO:0005887; C:integral to plasma membrane; ISS:SGD.
 GO:0005739; C:mitochondrion; IDA:SGD.
 GO:0015663; F:nicotinamide mononucleotide transmembrane transporter activity; IMP:SGD.
 GO:0015890; P:nicotinamide mononucleotide transport; IMP:SGD. 

Interpro

 IPR011701; MFS.
 IPR016196; MFS_dom_general_subst_transpt. 

Pfam

 PF07690; MFS_1 

SMART

  

PROSITE

  

PRINTS