UniProt Accession

 BASI_HUMAN; P35613; A6NJW1; D3YLG5; Q7Z796; Q8IZL7 

Genbank Protein ID

 X64364; D45131; L10240; M87879; L20471; AF042854; AF042848; AF042849; AF042850; AF042851; AF042852; AF042853; AB072923; AB085790; AF548371; GU557064; GU557065; AY358113; AY942196; AC005559; CH471242; CH471242; BC009040 

Genbank Nucleotide ID

 CAA45716.1; BAA08109.1; AAA68936.1; AAA91084.1; AAB41120.1; AAD10704.1; AAD10704.1; AAD10704.1; AAD10704.1; AAD10704.1; AAD10704.1; AAD10704.1; BAB88938.1; BAC76828.1; AAN40694.1; ADD31881.1; ADD31882.1; AAQ88480.1; AAX20110.1; AAC33279.1; EAW61181.1; EAW61185.1; AAH09040.1 

Protein Name

 Basigin 

Protein Synonyms/Alias

 5F7; Collagenase stimulatory factor; Extracellular matrix metalloproteinase inducer; EMMPRIN; Leukocyte activation antigen M6; OK blood group antigen; Tumor cell-derived collagenase stimulatory factor; TCSF; CD147 

Gene Name

 BSG 

Gene Synonyms/Alias

 UNQ6505/PRO21383 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
57	VTGHRWLKGGVVLKE	ubiquitination	[1]
63	LKGGVVLKEDALPGQ	ubiquitination	[1]
71	EDALPGQKTEFKVDS	ubiquitination	[1]
141	VTDWAWYKITDSEDK	ubiquitination	[1]
234	FIYEKRRKPEDVLDD	ubiquitination	[1]
250	DAGSAPLKSSGQHQN	ubiquitination	[1, 2]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931] 

Functional Description

 Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). May target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes (By similarity). 

Sequence Annotation

 DOMAIN 138 219 Ig-like C2-type.
 DOMAIN 221 315 Ig-like V-type.
 MOD_RES 362 362 Phosphoserine.
 CARBOHYD 160 160 N-linked (GlcNAc...).
 CARBOHYD 268 268 N-linked (GlcNAc...).
 CARBOHYD 302 302 N-linked (GlcNAc...) (Potential).
 DISULFID 157 203
 DISULFID 242 301  

Keyword

 3D-structure; Alternative promoter usage; Alternative splicing; Blood group antigen; Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Lectin; Mannose-binding; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 385 AA 

Protein Sequence

Gene Ontology

 GO:0002080; C:acrosomal membrane; IEA:Compara.
 GO:0000139; C:Golgi membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0045121; C:membrane raft; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0042383; C:sarcolemma; IEA:Compara.
 GO:0005537; F:mannose binding; IEA:UniProtKB-KW.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc.
 GO:0046697; P:decidualization; IEA:Compara.
 GO:0007566; P:embryo implantation; IEA:Compara.
 GO:0050900; P:leukocyte migration; TAS:Reactome.
 GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Compara.
 GO:0006090; P:pyruvate metabolic process; TAS:Reactome.
 GO:0051591; P:response to cAMP; IEA:Compara.
 GO:0046689; P:response to mercury ion; IEA:Compara.
 GO:0043434; P:response to peptide hormone stimulus; IEA:Compara. 

Interpro

 IPR009151; Basigin.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2. 

Pfam

 PF07679; I-set 

SMART

 SM00409; IG
 SM00408; IGc2 

PROSITE

 PS50835; IG_LIKE 

PRINTS