CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027215
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cytochrome P450, family 2, subfamily d, polypeptide 12 
Protein Synonyms/Alias
 MCG10954, isoform CRA_a; Protein Cyp2d12 
Gene Name
 Cyp2d12 
Gene Synonyms/Alias
 mCG_10954 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
116IFEHLGFKPRSQGMIubiquitination[1]
150RNFGLGRKSLEEWVIubiquitination[1]
286LAEIEKAKGNPESSFubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Heme; Iron; Metal-binding; Monooxygenase; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 504 AA 
Protein Sequence
MELLTGTDLW SVAIFTVIFI LLVDLMHRRQ SWTSCYPPGP VPWPVLGNLL QVDLNNMPYS 60
LYKLQNRYGD VFSLQMAWKP MVVINRMKAM KEVLLTCGED TADRPPVPIF EHLGFKPRSQ 120
GMIFAPYGPE WREQRRFSLS SLRNFGLGRK SLEEWVIKEA GHLCDAFTTQ AGQYINPNTM 180
LKKATCNVIA SLIFARRFEY EDPYLIRMLK VLEDSLTELS GLIPEVINTF PILLHIPRLA 240
DKFLQSQKSF IAIVDNLLTE NRTTWDPAQS PRNLTDAFLA EIEKAKGNPE SSFNDENLRM 300
VVIDLFTAGI LTTSTTLSWA LLLMILHPDV QRRVQQEIDE VIGQVRHPEM ADQAHMPYTN 360
AVIHEVQRFG DIVPLHLPRI TSRDIEVQDF LIPKGTILLP NMSSVHMDDT VWEKPLRFHP 420
EHFLDAQGHF VKHEAFITFS AGRRSCLGEP LARMELFLFF TCLLQRFSFS VPDGQPQPSD 480
HRVFSIMVAP SPYQLCAVIR EQGH 504 
Gene Ontology
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0016712; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; IEA:InterPro. 
Interpro
 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002401; Cyt_P450_E_grp-I.
 IPR008069; Cyt_P450_E_grp-I_CYP2D-like. 
Pfam
 PF00067; p450 
SMART
  
PROSITE
 PS00086; CYTOCHROME_P450 
PRINTS
 PR00463; EP450I.
 PR01686; EP450ICYP2D.
 PR00385; P450.