| Tag | Content |
|---|
| CPLM ID | CPLM-004749 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cytochrome P450 2C70 |
Protein Synonyms/Alias | CYPIIC70; Cytochrome P-450Md; Cytochrome P450 P49 |
Gene Name | Cyp2c70 |
Gene Synonyms/Alias | Cyp2c-70; Cyp2c22; P450md |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 193 | RFDYSDEKFQKFIEN | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. |
Sequence Annotation | METAL 434 434 Iron (heme axial ligand). |
Keyword | Complete proteome; Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; Oxidoreductase; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 489 AA |
Protein Sequence | MALFIFLGIW LSCLVFLFLW NQHHVRRKLP PGPTPLPIFG NILQVGVKNI SKSMCMLAKE 60
YGPVFTMYLG MKPTVVLYGY EVLKEALIDR GEEFSDKMHS SMLSKVSQGL GIVFSNGEIW 120
KQTRRFSLMV LRSMGMGKRT IENRIQEEVV YLLEALRKTN GSPCDPSFLL ACVPCNVISS 180
VIFQHRFDYS DEKFQKFIEN FHTKIEILAS PWAQLCSAYP VLYYLPGIHN KFLKDVTEQK 240
KFILMEINRH RASLNLSNPQ DFIDYFLIKM EKEKHNEKSE FTMDNLIVTI GDLFGAGTET 300
TSSTIKYGLL LLLKYPEVTA KIQEEITRVI GRHRRPCMQD RNHMPYTDAV LHEIQRYIDF 360
VPIPLPRKTT QDVEFRGYHI PKGTSVMACL TSALHDDKEF PNPEKFDPGH FLDEKGNFKK 420
SDYFMAFSAG RRACIGEGLA RMEMFLILTS ILQHFTLKPL VNPEDIDTTP VQPGLLSVPP 480
PFELCFIPV 489 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0043231; C:intracellular membrane-bounded organelle; NAS:UniProtKB. GO:0070330; F:aromatase activity; IEA:EC. GO:0009055; F:electron carrier activity; IEA:InterPro. GO:0020037; F:heme binding; IEA:InterPro. GO:0005506; F:iron ion binding; IEA:InterPro. GO:0004497; F:monooxygenase activity; NAS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |