CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037292
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Phosphoribosylaminoimidazolecarboxamide formyltransferase 
Protein Synonyms/Alias
  
Gene Name
 ATIC 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
38VASGGTAKALRDAGLubiquitination[1, 2]
253WQLVKELKEALGIPAubiquitination[2, 3]
265IPAAASFKHVSPAGAacetylation[4]
265IPAAASFKHVSPAGAubiquitination[2, 3]
284PLSEDEAKVCMVYDLubiquitination[2]
293CMVYDLYKTLTPISAubiquitination[2]
330VCDVPTAKIISREVSubiquitination[2, 5, 6, 7]
355EALTILSKKKNGNYCacetylation[3, 4]
355EALTILSKKKNGNYCubiquitination[1, 2, 8, 9]
356ALTILSKKKNGNYCVubiquitination[2, 3]
357LTILSKKKNGNYCVLubiquitination[2]
371LQMDQSYKPDENEVRubiquitination[2]
388FGLHLSQKRNNGVVDubiquitination[1, 2]
396RNNGVVDKSLFSNVVubiquitination[1, 2, 3, 7, 8]
405LFSNVVTKNKDLPESubiquitination[1, 2, 7, 8, 9]
407SNVVTKNKDLPESALubiquitination[2, 3]
436SNSVCYAKNGQVIGIubiquitination[2, 3, 5, 7]
460CTRLAGDKANYWWLRubiquitination[2, 3]
476HPQVLSMKFKTGVKRubiquitination[2]
506GEDEDLIKWKALFEEubiquitination[8]
508DEDLIKWKALFEEVPubiquitination[9]
523ELLTEAEKKEWVEKLubiquitination[3, 8]
524LLTEAEKKEWVEKLTubiquitination[2]
529EKKEWVEKLTEVSISubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [6] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [7] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [8] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [9] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 591 AA 
Protein Sequence
MSSLSALFSV SDKTGLVEFA RNLTALGLNL VASGGTAKAL RDAGLAVRDV SELTGFPEML 60
GGRVKTLHPA VHAGILARNI PEDNADMARL DFNLIRVVAC NLYPFVKTVA SPGVTVEEAV 120
EQIDIGGVTL LRAAAKNHAR VTVVCEPEDY VVVSTEMQSS ESKDTSLETR RQLALKAFTH 180
TAQYDEAISD YFRKQYSKGV SQMPLRYGMN PHQTPAQLYT LQPKLPITVL NGAPGFINLC 240
DALNAWQLVK ELKEALGIPA AASFKHVSPA GAAVGIPLSE DEAKVCMVYD LYKTLTPISA 300
AYARARGADR MSSFGDFVAL SDVCDVPTAK IISREVSDGI IAPGYEEEAL TILSKKKNGN 360
YCVLQMDQSY KPDENEVRTL FGLHLSQKRN NGVVDKSLFS NVVTKNKDLP ESALRDLIVA 420
TIAVKYTQSN SVCYAKNGQV IGIGAGQQSR IHCTRLAGDK ANYWWLRHHP QVLSMKFKTG 480
VKRAEISNAI DQYVTGTIGE DEDLIKWKAL FEEVPELLTE AEKKEWVEKL TEVSISSDAF 540
FPFRDNVDRA KRSGVAYIAA PSGSAADKVV IEACDELGII LAHTNLRLFH H 591 
Gene Ontology
 GO:0003937; F:IMP cyclohydrolase activity; IEA:InterPro.
 GO:0004643; F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity; IEA:InterPro.
 GO:0006164; P:purine nucleotide biosynthetic process; IEA:InterPro. 
Interpro
 IPR024051; AICAR_Tfase_dom.
 IPR024050; AICAR_Tfase_insert_dom.
 IPR002695; AICARFT_IMPCHas.
 IPR016193; Cytidine_deaminase-like.
 IPR011607; MGS-like_dom. 
Pfam
 PF01808; AICARFT_IMPCHas
 PF02142; MGS 
SMART
 SM00798; AICARFT_IMPCHas
 SM00851; MGS 
PROSITE
  
PRINTS