CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017235
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein LSM14 homolog A 
Protein Synonyms/Alias
 Protein FAM61A; RNA-associated protein 55A; mRAP55A 
Gene Name
 Lsm14a 
Gene Synonyms/Alias
 Fam61a; Rap55a 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
11GTPYIGSKISLISKAacetylation[1]
17SKISLISKAEIRYEGacetylation[1]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
 Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs (By similarity). 
Sequence Annotation
 DOMAIN 283 319 DFDF.
 MOTIF 360 376 FFD box.
 MOTIF 379 399 TFG box.
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 182 182 Phosphoserine (By similarity).
 MOD_RES 183 183 Phosphoserine.
 MOD_RES 192 192 Phosphoserine (By similarity).
 MOD_RES 194 194 Phosphothreonine (By similarity).
 MOD_RES 216 216 Phosphoserine.  
Keyword
 Acetylation; Complete proteome; Cytoplasm; Developmental protein; Phosphoprotein; Reference proteome; Repressor; Ribonucleoprotein; Translation regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 462 AA 
Protein Sequence
MSGGTPYIGS KISLISKAEI RYEGILYTID TENSTVALAK VRSFGTEDRP TDRPIPPRDE 60
VFEYIIFRGS DIKDLTVCEP PKPQCSLPQD PAIVQSSLGS SSSSFQSVGS YGPFGRMPAY 120
SQFSPSTLVG QQFGAVGVAG NSLTSFGTEA SNSGTLSQSN AVGSAFTQDT RSVKPQLAQG 180
RSSPQLDPLR KSPTMEQAVQ TASAHLPAPA PVGRRSPVPA RPLPPTSQKA IDNQEHRRAE 240
VHKVPRPENE QLRNDKRQVV PGVPSAPRRG RGGHRGGRGR FGIRRDGPMK FEKDFDFESA 300
NAQFNKEEID REFHNKLKLK EDKLEKQEKP VNGEDKGDSG VDTQNSEGNA DEEDPLGPNC 360
YYDKTKSFFD NISCDDNRER RPTWAEERRL NAETFGIPLR PNRGRGGYRG RGGLGFRGGR 420
GRGSGRGGTF TAPRGFRAGF RGARGGREFA DFEYRKTTAF GP 462 
Gene Ontology
 GO:0000932; C:cytoplasmic mRNA processing body; ISS:UniProtKB.
 GO:0010494; C:cytoplasmic stress granule; ISS:UniProtKB.
 GO:0043231; C:intracellular membrane-bounded organelle; IEA:Compara.
 GO:0003690; F:double-stranded DNA binding; IDA:MGI.
 GO:0003725; F:double-stranded RNA binding; IDA:MGI.
 GO:0003727; F:single-stranded RNA binding; IDA:MGI.
 GO:0033962; P:cytoplasmic mRNA processing body assembly; ISS:UniProtKB.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0060340; P:positive regulation of type I interferon-mediated signaling pathway; IDA:MGI.
 GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
 GO:0039529; P:RIG-I signaling pathway; IGI:MGI. 
Interpro
 IPR025762; DFDF.
 IPR019050; FDF_dom.
 IPR025761; FFD_box.
 IPR025609; Lsm14_N.
 IPR010920; LSM_dom.
 IPR025768; TFG_box. 
Pfam
 PF09532; FDF
 PF12701; LSM14 
SMART
  
PROSITE
 PS51512; DFDF
 PS51513; FFD
 PS51536; TFG 
PRINTS