UniProt Accession

 BIN3_HUMAN; Q9NQY0; Q9BVG2; Q9NVY9 

Genbank Protein ID

 AF271732; AK001289; AK023980; BC001223; BC009824 

Genbank Nucleotide ID

 AAF76218.1; BAA91603.1; BAB14751.1; AAH01223.1; AAH09824.1 

Protein Name

 Bridging integrator 3 

Protein Synonyms/Alias

  

Gene Name

 BIN3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
7	*MSWIPFKIGQPKKQ	ubiquitination	[1, 2]
12	PFKIGQPKKQIVPKT	ubiquitination	[2]
18	PKKQIVPKTVERDFE	ubiquitination	[2]
30	DFEREYGKLQQLEEQ	ubiquitination	[2]
47	RLQKDMKKSTDADLA	ubiquitination	[2]
57	DADLAMSKSAVKISL	ubiquitination	[2]
99	MDAFNQEKVNQIQKT	ubiquitination	[2]
105	EKVNQIQKTVIEPLK	ubiquitination	[2]
112	KTVIEPLKKFGSVFP	ubiquitination	[2]
113	TVIEPLKKFGSVFPS	ubiquitination	[2]
126	PSLNMAVKRREQALQ	ubiquitination	[1, 2]
141	DYRRLQAKVEKYEEK	ubiquitination	[2]
157	KTGPVLAKLHQAREE	ubiquitination	[2]
240	RERENEAKLSELRAL	ubiquitination	[2]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Involved in cytokinesis and septation where it has a role in the localization of F-actin. 

Sequence Annotation

 DOMAIN 9 232 BAR.  

Keyword

 Alternative splicing; Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Reference proteome; Septation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 253 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0008093; F:cytoskeletal adaptor activity; NAS:UniProtKB.
 GO:0007015; P:actin filament organization; NAS:UniProtKB.
 GO:0000917; P:barrier septum assembly; IEA:UniProtKB-KW.
 GO:0000910; P:cytokinesis; NAS:UniProtKB.
 GO:0008104; P:protein localization; IMP:UniProtKB.
 GO:0009826; P:unidimensional cell growth; IMP:UniProtKB. 

Interpro

 IPR027267; AH/BAR-dom.
 IPR004148; BAR_dom. 

Pfam

 PF03114; BAR 

SMART

 SM00721; BAR 

PROSITE

 PS51021; BAR 

PRINTS