CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031485
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Peroxisomal targeting signal 1 receptor 
Protein Synonyms/Alias
 cDNA FLJ56404, highly similar to Peroxisomal targeting signal 1 receptor 
Gene Name
 PEX5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
49AGHFTQDKALRQEGLacetylation[1, 2]
104SRAPQTFKMDDLLAEubiquitination[3]
230VAKVDDPKLANSEFLubiquitination[3, 4, 5]
238LANSEFLKFVRQIGEubiquitination[2, 3, 4, 5]
299DMEFERAKSAIESDVubiquitination[6]
477GAGLGPSKRILGSLLubiquitination[2, 3, 4, 5, 6, 7, 8]
548NDYLLWNKLGATLANubiquitination[7]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [6] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [7] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [8] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Receptor; Reference proteome; Repeat; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 660 AA 
Protein Sequence
MLLCRAHRVL GLRGARELAV TMAMRELVEA ECGGANPLMK LAGHFTQDKA LRQEGLRPGP 60
WPPGAPASEA ASKPLGVASE DELVAEFLQD QNAPLVSRAP QTFKMDDLLA EMQQIEQSNF 120
RQAPQRAPGV ADLALSENWA QEFLAAGDAV DVTQDYNETD WSQEFISEVT DPLSVSPARW 180
AEEYLEQSEE KLWLGEPEGT ATDRWYDEYH PEEDLQHTAS DFVAKVDDPK LANSEFLKFV 240
RQIGEGQVSL ESGAGSGRAQ AEQWAAEFIQ QQGTSDAWVD QFTRPVNTSA LDMEFERAKS 300
AIESDVDFWD KLQAELEEMA KRDAEAHPWL SDYDDLTSAT YDKGYQFEEE NPLRDHPQPF 360
EEGLRRLQEG DLPNAVLLFE AAVQQDPKHM EAWQYLGTTQ AENEQELLAI SALRRCLELK 420
PDNQTALMAL AVSFTNESLQ RQACETLRDW LRYTPAYAHL VTPAEEGAGG AGLGPSKRIL 480
GSLLSDSLFL EVKELFLAAV RLDPTSIDPD VQCGLGVLFN LSGEYDKAVD CFTAALSVRP 540
NDYLLWNKLG ATLANGNQSE EAVAAYRRAL ELQPGYIRSR YNLGISCINL GAHREAVEHF 600
LEALNMQRKS RGPRGEGGAM SENIWSTLRL ALSMLGQSDA YGAADARDLS TLLTMFGLPQ 660 
Gene Ontology
 GO:0005794; C:Golgi apparatus; IDA:HPA. 
Interpro
 IPR024111; PTS1R_family.
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 
Pfam
 PF00515; TPR_1 
SMART
 SM00028; TPR 
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS