| Tag | Content |
|---|
| CPLM ID | CPLM-013783 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Integrator complex subunit 11 |
Protein Synonyms/Alias | Int11; Cleavage and polyadenylation-specific factor 3-like protein; CPSF3-like protein |
Gene Name | CPSF3L |
Gene Synonyms/Alias | INTS11 |
Created Date | July 27, 2013 |
Organism | Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
NCBI Taxa ID | 9601 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 262 | FWERMNLKVPIYFST | ubiquitination | [1] | | 280 | EKANHYYKLFIPWTN | ubiquitination | [1] | | 289 | FIPWTNQKIRKTFVQ | ubiquitination | [1] | | 303 | QRNMFEFKHIKAFDR | ubiquitination | [1] | | 474 | QGLLPEAKKPRLLHG | ubiquitination | [1] | | 475 | GLLPEAKKPRLLHGT | ubiquitination | [1] | | 486 | LHGTLIMKDSNFRLV | ubiquitination | [1] | | 500 | VSSEQALKELGLAEH | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage (By similarity). |
Sequence Annotation | MOTIF 68 73 HXHXDH motif. |
Keyword | Complete proteome; Cytoplasm; Hydrolase; Nucleus; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 600 AA |
Protein Sequence | MPEIRVTPLG AGQDVGRSCI LVSIAGKNVM LDCGMHMGFN DDRRFPDFSY ITQNGRLTDF 60
LDCVIISHFH LDHCGALPYF SEMVGYDGPI YMTHPTQAIC PILLEDYRKI AVDKKGEANF 120
FTSQMIKDCM KKVVAVHLHQ TVQVDDELEI KAYYAGHVLG AAMFQIKVGS ESVVYTGDYN 180
MTPDRHLGAA WIDKCRPNLL ITESTYATTI RDSKRCRERD FLKKVHETVE RGGKVLIPVF 240
ALGRAQELCI LLETFWERMN LKVPIYFSTG LTEKANHYYK LFIPWTNQKI RKTFVQRNMF 300
EFKHIKAFDR AFADNPGPMV VFATPGMLHA GQSLQIFRKW AGNEKNMVIM PGYCVQGTVG 360
HKILSGQRKL EMEGRQVLEV KMQVEYMSFS AHADAKGIMQ LVGQAEPESV LLVHGEAKKM 420
EFLKQKIEQE LRVSCYMPAN GETVTLPTSP SIPVGISLGL LKREMAQGLL PEAKKPRLLH 480
GTLIMKDSNF RLVSSEQALK ELGLAEHQLR FTCRVHLHDT RKEQETALRV YSHLKSILKD 540
HCVQHLPDGS VTVESILIQA AAPSEDPGTK VLLVSWTYQD EELGSFLTSL LKKGLPQAPS 600 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |