CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013771
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 WD repeat domain phosphoinositide-interacting protein 3 
Protein Synonyms/Alias
 WIPI-3; WD repeat-containing protein 45-like; WDR45-like protein; WD repeat-containing protein 45B; WIPI49-like protein 
Gene Name
 WDR45B 
Gene Synonyms/Alias
 WDR45L; WIPI3 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
42VYNTDPLKEKEKQEFubiquitination[1]
206RIATASEKGTLIRIFubiquitination[2, 3, 4]
266AEDPKRNKQSSLASAubiquitination[2, 3]
278ASASFLPKYFSSKWSubiquitination[3, 5, 6]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [6] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
  
Sequence Annotation
 REPEAT 183 223 WD 1.
 REPEAT 228 267 WD 2.  
Keyword
 Complete proteome; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 344 AA 
Protein Sequence
MNLLPCNPHG NGLLYAGFNQ DHGCFACGME NGFRVYNTDP LKEKEKQEFL EGGVGHVEML 60
FRCNYLALVG GGKKPKYPPN KVMIWDDLKK KTVIEIEFST EVKAVKLRRD RIVVVLDSMI 120
KVFTFTHNPH QLHVFETCYN PKGLCVLCPN SNNSLLAFPG THTGHVQLVD LASTEKPPVD 180
IPAHEGVLSC IALNLQGTRI ATASEKGTLI RIFDTSSGHL IQELRRGSQA ANIYCINFNQ 240
DASLICVSSD HGTVHIFAAE DPKRNKQSSL ASASFLPKYF SSKWSFSKFQ VPSGSPCICA 300
FGTEPNAVIA ICADGSYYKF LFNPKGECIR DVYAQFLEMT DDKL 344 
Gene Ontology
 GO:0005737; C:cytoplasm; IBA:RefGenome.
 GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IBA:RefGenome.
 GO:0032266; F:phosphatidylinositol-3-phosphate binding; IBA:RefGenome.
 GO:0000045; P:autophagic vacuole assembly; IBA:RefGenome. 
Interpro
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS