CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013823
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Major facilitator superfamily domain-containing protein 1 
Protein Synonyms/Alias
  
Gene Name
 MFSD1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 
NCBI Taxa ID
 9601 
Lysine Modification
Position
Peptide
Type
References
255GKTGEVIKLTDVKDFubiquitination[1]
460ARQREEIKFSHTE**ubiquitination[1, 2]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 465 AA 
Protein Sequence
MEEEDEEARA LLAGGPDEAD RGAPAAPGAL PALCDPSRLV HRLLVLLLMC FLGFGSYFCY 60
DNPAALQTQV KRDMQVNTTK FMLLYAWYSW SNVVLCFFGG FLIDRVFGIR WGTIIFSCFV 120
CIGQVVFALG GIFNAFWLME FGRFVFGIGG ESLAVAQNTY AVSWFKGKEL NLVFGLQLSM 180
ARIGSTVNMN LMGWLYSKIE ALLGSAGHTT LGITLMIGGV TCILSLICAL ALAYLDQRAE 240
RILHKEQGKT GEVIKLTDVK DFSLPLWLIF IICVCYYVAV FPFIGLGKVF FTEKFGFSSQ 300
AASAINSVVY VISAPMSPVF GLLVDKTGKN IIWVLCAVAA TLVSHMMLAF TMWNPWIAMC 360
LLGLSYSLLA CALWPMVAFV VPEHQLGTAH GFMQSIQNLG LAIISIIAGM ILDSRGYLFL 420
EVFFIACVSL SLLSVVLLYL VNRAQGGNLN YSARQREEIK FSHTE 465 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0055085; P:transmembrane transport; IEA:InterPro. 
Interpro
 IPR011701; MFS.
 IPR020846; MFS_dom.
 IPR016196; MFS_dom_general_subst_transpt. 
Pfam
 PF07690; MFS_1 
SMART
  
PROSITE
 PS50850; MFS 
PRINTS