CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010806
UniProt Accession
Genbank Protein ID
 M83651 
Genbank Nucleotide ID
Protein Name
 Beta-1,4 N-acetylgalactosaminyltransferase 1 
Protein Synonyms/Alias
 (N-acetylneuraminyl)-galactosylglucosylceramide; GM2/GD2 synthase; GalNAc-T 
Gene Name
 B4GALNT1 
Gene Synonyms/Alias
 GALGT; SIAT2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
104VRAIDLTKAFDPAELubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Involved in the biosynthesis of gangliosides GM2, GD2 and GA2. 
Sequence Annotation
 CARBOHYD 79 79 N-linked (GlcNAc...) (Potential).
 CARBOHYD 179 179 N-linked (GlcNAc...) (Potential).
 CARBOHYD 274 274 N-linked (GlcNAc...) (Potential).
 DISULFID 80 80 Interchain (with C-412).
 DISULFID 82 82 Interchain (with C-529).
 DISULFID 412 412 Interchain (with C-80).
 DISULFID 429 476
 DISULFID 529 529 Interchain (with C-82).  
Keyword
 Complete proteome; Disulfide bond; Glycoprotein; Glycosyltransferase; Golgi apparatus; Membrane; Polymorphism; Reference proteome; Signal-anchor; Transferase; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 533 AA 
Protein Sequence
MWLGRRALCA LVLLLACASL GLLYASTRDA PGLRLPLAPW APPQSPRRPE LPDLAPEPRY 60
AHIPVRIKEQ VVGLLAWNNC SCESSGGGLP LPFQKQVRAI DLTKAFDPAE LRAASATREQ 120
EFQAFLSRSQ SPADQLLIAP ANSPLQYPLQ GVEVQPLRSI LVPGLSLQAA SGQEVYQVNL 180
TASLGTWDVA GEVTGVTLTG EGQADLTLVS PGLDQLNRQL QLVTYSSRSY QTNTADTVRF 240
STEGHEAAFT IRIRHPPNPR LYPPGSLPQG AQYNISALVT IATKTFLRYD RLRALITSIR 300
RFYPTVTVVI ADDSDKPERV SGPYVEHYLM PFGKGWFAGR NLAVSQVTTK YVLWVDDDFV 360
FTARTRLERL VDVLERTPLD LVGGAVREIS GFATTYRQLL SVEPGAPGLG NCLRQRRGFH 420
HELVGFPGCV VTDGVVNFFL ARTDKVREVG FDPRLSRVAH LEFFLDGLGS LRVGSCSDVV 480
VDHASKLKLP WTSRDAGAET YARYRYPGSL DESQMAKHRL LFFKHRLQCM TSQ 533 
Gene Ontology
 GO:0030173; C:integral to Golgi membrane; IEA:InterPro.
 GO:0016020; C:membrane; TAS:ProtInc.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0003947; F:(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity; TAS:ProtInc.
 GO:0005975; P:carbohydrate metabolic process; TAS:ProtInc.
 GO:0001574; P:ganglioside biosynthetic process; IEA:Compara.
 GO:0006687; P:glycosphingolipid metabolic process; TAS:ProtInc.
 GO:0030259; P:lipid glycosylation; IEA:InterPro.
 GO:0019915; P:lipid storage; IEA:Compara.
 GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
 GO:0007283; P:spermatogenesis; IEA:Compara. 
Interpro
 IPR001173; Glyco_trans_2.
 IPR011143; GM2_synthase. 
Pfam
 PF00535; Glycos_transf_2 
SMART
  
PROSITE
  
PRINTS