CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016752
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 U3 small nucleolar RNA-associated protein 15 homolog 
Protein Synonyms/Alias
 Src-associated protein SAW 
Gene Name
 Utp15 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
80VKTFSRFKDTAYCATacetylation[1]
190GSYDHTVKIFDARTNacetylation[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
 Involved in nucleolar processing of pre-18S ribosomal RNA (By similarity). 
Sequence Annotation
 REPEAT 36 75 WD 1.
 REPEAT 78 117 WD 2.
 REPEAT 120 159 WD 3.
 REPEAT 162 202 WD 4.
 REPEAT 204 242 WD 5.
 REPEAT 246 285 WD 6.
 REPEAT 287 326 WD 7.
 MOD_RES 2 2 N-acetylalanine (By similarity).  
Keyword
 Acetylation; Complete proteome; Nucleus; Reference proteome; Repeat; rRNA processing; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 528 AA 
Protein Sequence
MAGYKPVAIQ TYPVLGEKIT QDTLYWNNYK TPVQIKEFGA VSKVDFSPQL PYNYAVTASS 60
RIHIYGRYSQ EPVKTFSRFK DTAYCATFRQ DGQLLVAGSE DGVVQLFDIN GRAPLRQFEG 120
HTKAVHTVDF TADNYHVVSG ADDYTVKLWD IPNSKEILTF KEHSDYVRCG CASKLNPDLF 180
VTGSYDHTVK IFDARTNKNV LCVEHGQPVE SVLLFPSGGL LVSAGGRYVK VWDMLKGGQL 240
LVSLKNHHKT VTCLCLSSSG QRLLSGSLDR KVKVYSTTSY KVVHSFDYAA SILSLALSHQ 300
DETIVVGMTN GILSVKHRKS EAKKTSLPRR RRPAYRTFIK GKNYLKQRDD IMVSRPAKKH 360
LEGYDKDLKS FRVSQALDRV LEPKCVIRTP EVTVSIIKEL TRRGVLANAL AGRDEKEVTR 420
VLNFLIRNLS QPRFAPVLIN AAEIIIDIYL PVIGQSSVVD KKFIVLQELV EKEIDYQREL 480
LETLGMMDML FATMTRNDSD PVPEHVPAEL PEEKTESPTQ PSDTDKNS 528 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0006364; P:rRNA processing; IEA:UniProtKB-KW. 
Interpro
 IPR020472; G-protein_beta_WD-40_rep.
 IPR018983; U3_snoRNA-assocProt_15_C.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF09384; UTP15_C
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR00320; GPROTEINBRPT.