CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017603
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 LEM domain-containing protein 2 
Protein Synonyms/Alias
 hLEM2 
Gene Name
 LEMD2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
494MLVWRWTKPSSFSDSubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Involved in nuclear structure organization. 
Sequence Annotation
 DOMAIN 1 42 LEM.
 REGION 74 103 Interaction with lamin A/C complexes.
 MOD_RES 497 497 Phosphoserine.
 MOD_RES 499 499 Phosphoserine.
 MOD_RES 501 501 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Membrane; Nucleus; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 503 AA 
Protein Sequence
MAGLSDLELR RELQALGFQP GPITDTTRDV YRNKLRRLRG EARLRDEERL REEARPRGEE 60
RLREEARLRE DAPLRARPAA ASPRAEPWLS QPASGSAYAT PGAYGDIRPS AASWVGSRGL 120
AYPARPAQLR RRASVRGSSE EDEDARTPDR ATQGPGLAAR RWWAASPAPA RLPSSLLGPD 180
PRPGLRATRA GPAGAARARP EVGRRLERWL SRLLLWASLG LLLVFLGILW VKMGKPSAPQ 240
EAEDNMKLLP VDCERKTDEF CQAKQKAALL ELLHELYNFL AIQAGNFECG NPENLKSKCI 300
PVMEAQEYIA NVTSSSSAKF EAALTWILSS NKDVGIWLKG EDQSELVTTV DKVVCLESAH 360
PRMGVGCRLS RALLTAVTNV LIFFWCLAFL WGLLILLKYR WRKLEEEEQA MYEMVKKIID 420
VVQDHYVDWE QDMERYPYVG ILHVRDSLIP PQSRRRMKRV WDRAVEFLAS NESRIQTESH 480
RVAGEDMLVW RWTKPSSFSD SER 503 
Gene Ontology
 GO:0005639; C:integral to nuclear inner membrane; IDA:MGI.
 GO:0043409; P:negative regulation of MAPK cascade; IEA:Compara.
 GO:0035914; P:skeletal muscle cell differentiation; IGI:MGI. 
Interpro
 IPR018996; Inner-Nucl-membr_MAN1.
 IPR011015; LEM/LEM-like_dom.
 IPR003887; LEM_dom. 
Pfam
 PF03020; LEM
 PF09402; MSC 
SMART
 SM00540; LEM 
PROSITE
 PS50954; LEM 
PRINTS