CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033222
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Endothelial PAS domain-containing protein 1 
Protein Synonyms/Alias
  
Gene Name
 EPAS1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
68ISFLRTHKLLSSVCSubiquitination[1]
186RGRTVNLKSATWKVLubiquitination[1]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; DNA-binding; Nucleus; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 259 AA 
Protein Sequence
MTADKEKKRS SSERRKEKSR DAARCRRSKE TEVFYELAHE LPLPHSVSSH LDKASIMRLA 60
ISFLRTHKLL SSVCSENESE AEADQQMDNL YLKALEGFIA VVTQDGDMIF LSENISKFMG 120
LTQVELTGHS IFDFTHPCDH EEIRENLSLK NGSGFGKKSK DMSTERDFFM RMKCTVTNRG 180
RTVNLKSATW KVLHCTGQVK VYNNCPPHNS LCGYKEPLLS CLIIMCEPIQ HPSHMDIPLD 240
SKTFLSRHSM DMKFTYCDD 259 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005667; C:transcription factor complex; IEA:Compara.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IEA:Compara.
 GO:0004871; F:signal transducer activity; IEA:InterPro.
 GO:0001525; P:angiogenesis; IEA:Compara.
 GO:0001974; P:blood vessel remodeling; IEA:Compara.
 GO:0048469; P:cell maturation; IEA:Compara.
 GO:0001892; P:embryonic placenta development; IEA:Compara.
 GO:0030218; P:erythrocyte differentiation; IEA:Compara.
 GO:0030324; P:lung development; IEA:Compara.
 GO:0007005; P:mitochondrion organization; IEA:Compara.
 GO:0048625; P:myoblast fate commitment; IEA:Compara.
 GO:0042415; P:norepinephrine metabolic process; IEA:Compara.
 GO:0002027; P:regulation of heart rate; IEA:Compara.
 GO:0043619; P:regulation of transcription from RNA polymerase II promoter in response to oxidative stress; IEA:Compara.
 GO:0043129; P:surfactant homeostasis; IEA:Compara.
 GO:0007601; P:visual perception; IEA:Compara. 
Interpro
 IPR011598; bHLH_dom.
 IPR001067; Nuc_translocat.
 IPR000014; PAS.
 IPR013767; PAS_fold. 
Pfam
 PF00989; PAS 
SMART
 SM00353; HLH
 SM00091; PAS 
PROSITE
 PS50888; BHLH
 PS50112; PAS 
PRINTS
 PR00785; NCTRNSLOCATR.