CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042479
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Histone-lysine N-methyltransferase MLL3 
Protein Synonyms/Alias
  
Gene Name
 KMT2C 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
300LSMETPAKTEEIKLEacetylation[1]
562VTKTLGPKPFQLPFRacetylation[2, 3]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Methyltransferase; Nucleus; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1524 AA 
Protein Sequence
LMQEVDRQRA LQQRMEMEQH GMVGSEISSS RTSVSQIPFY SSDLPCDFMQ PLGPLQQSPQ 60
HQQQMGQVLQ QQNIQQGSIN SPSTQTFMQT NERRQVGPPS FVPDSPSIPV GSPNFSSVKQ 120
GHGNLSGTSF QQSPVRPSFT PALPAAPPVA NSSLPCGQDS TITHGHSYPG STQSLIQLYS 180
DIIPEEKGKK KRTRKKKRDD DAESTKAPST PHSDITAPPT PGISETTSTP AVSTPSELPQ 240
QADQESVEPV GPSTPNMAAG QLCTELENKL PNSDFSQATP NQQTYANSEV DKLSMETPAK 300
TEEIKLEKAE TESCPGQEEP KLEEQNGSKV EGNAVACPVS SAQSPPHSAG APAAKGDSGN 360
ELLKHLLKNK KSSSLLNQKP EGSICSEDDC TKDNKLVEKQ NPAEGLQTLG AQMQGGFGCG 420
NQLPKTDGGS ETKKQRSKRT QRTGEKAAPR SKKRKKDEEE KQAMYSSTDT FTHLKQQLSL 480
LPLMEPIIGV NFAHFLPYGS GQFNSGNRLL GTFGSATLEG VSDYYSQLIY KKMANGFATT 540
EELAGKAGVL VSHEVTKTLG PKPFQLPFRP QDDLLARALA QGPKTVDVPA SLPTPPHNNQ 600
EELRIQDHCG DRDTPDSFVP SSSPESVVGV EVSRYPDLSL VKEEPPEPVP SPIIPILPST 660
AGKSSESRRN DIKTEPGTLY FASPFGPSPN GPRSGLISVA ITLHPTAAEN ISSVVAAFSD 720
LLHVRIPNSY EVSSAPDVPS MGLVSSHRIN PGLEYRQHLL LRGPPPGSAN PPRLVSSYRL 780
KQPNVPFPPT SNGLSGYKDS SHGIAESAAL RPQWCCHCKV VILGSGVRKS FKDLTLLNKD 840
SRESTKRVEK DIVFCSNNCF ILYSSTAQAK NSENKESIPS LPQSPMRETP SKAFHQYSNN 900
ISTLDVHCLP QLPEKASPPA SPPIAFPPAF EAAQVEAKPD ELKVTVKLKP RLRAVHGGFE 960
DCRPLNKKWR GMKWKKWSIH IVIPKGTFKP PCEDEIDEFL KKLGTSLKPD PVPKDYRKCC 1020
FCHEEGDGLT DGPARLLNLD LDLWVHLNCA LWSTEVYETQ AGALINVELA LRRGLQMKCV 1080
FCHKTGATSG CHRFRCTNIY HFTCAIKAQC MFFKDKTMLC PMHKPKGIHE QELSYFAVFR 1140
RVYVQRDEVR QIASIVQRGE RDHTFRVGSL IFHTIGQLLP QQMQAFHSPK ALFPVGYEAS 1200
RLYWSTRYAN RRCRYLCSIE EKDGRPVFVI RIVEQGHEDL VLSDISPKGV WDKILEPVAC 1260
VRKKSEMLQL FPAYLKGEDL FGLTVSAVAR IAESLPGVEA CENYTFRYGR NPLMELPLAV 1320
NPTGCARSEP KMSAHVKRPH TLNSTSTSKS FQSTVTGELN APYSKQFVHS KSSQYRKMKT 1380
EWKSNVYLAR SRIQGLGLYA ARDIEKHTMV IEYIGTIIRN EVANRKEKLY ESQNRGVYMF 1440
RMDNDHVIDA TLTGGPARYI NHSCAPNCVA EVVTFERGHK IIISSSRRIQ KGEELCYDYK 1500
FDFEDDQHKI PCHCGAVNCR KWMN 1524 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-KW.
 GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR003889; FYrich_C.
 IPR003888; FYrich_N.
 IPR003616; Post-SET_dom.
 IPR001214; SET_dom.
 IPR001965; Znf_PHD. 
Pfam
 PF05965; FYRC
 PF05964; FYRN
 PF00856; SET 
SMART
 SM00542; FYRC
 SM00541; FYRN
 SM00249; PHD
 SM00508; PostSET
 SM00317; SET 
PROSITE
 PS51543; FYRC
 PS51542; FYRN
 PS50868; POST_SET
 PS50280; SET 
PRINTS