UniProt Accession

 B4E3L6_HUMAN; B4E3L6; E7ENP2 

Genbank Protein ID

 AC114730; AK304773 

Genbank Nucleotide ID

 BAG65528.1 

Protein Name

 D-2-hydroxyglutarate dehydrogenase, mitochondrial 

Protein Synonyms/Alias

 cDNA FLJ61087, highly similar to D-2-hydroxyglutarate dehydrogenase, mitochondrial (EC 1.1.99.-) 

Gene Name

 D2HGDH 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
64	LPFSTVSKQDLAAFE	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 319 AA 

Protein Sequence

Gene Ontology

 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
 GO:0008762; F:UDP-N-acetylmuramate dehydrogenase activity; IEA:InterPro. 

Interpro

 IPR016169; CO_DH_flavot_FAD-bd_sub2.
 IPR016166; FAD-bd_2.
 IPR016167; FAD-bd_2_sub1.
 IPR006094; Oxid_FAD_bind_N. 

Pfam

 PF01565; FAD_binding_4 

SMART

  

PROSITE

 PS51387; FAD_PCMH 

PRINTS