CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-045524
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Smg1 
Protein Synonyms/Alias
  
Gene Name
 Smg1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
171LATVKQLKEFIQQPEacetylation[1]
3548DVMSQNAKKLIQKNLubiquitination[2]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 3649 AA 
Protein Sequence
MSRRAPGSRL SSGGGGTKYP RSWNDWQPRT DSASADPDTL KYSSSRDRGV SSSYGLQPSN 60
SAVVSRQRHD DTRGHADIQN DEKGSYCLIY SSKKNKSNRF LWAREMEMVQ WLGALFTLTQ 120
HPSAQNRSRK PNKVTERSMS YSDESRLSNL LRRITREDDR DRRLATVKQL KEFIQQPENK 180
LVLVKQLDNI LAAVHDVLNE SSKLLQELRQ EGACCLGLLC ASLSYEAEKI FKWIFSKFSS 240
SAKDEVKLLY LCATYRALET VGEKKAFSSV MQLVMTSLQS ILENVDTPEL LCKCVKCILL 300
VARCYPHIFS TNFRDTVDIL VGWHIDHTQK PSLTQQVSGW LQSLEPFWVA DLAFSTTLLG 360
QFLEDMEAYA EDLSHVASGE SVDEDVPPPS VSLPKLAALL RVFSTVVRSI GERFSPIRGP 420
PITEAYVTDV LYRVMRCVTA ANQVFFSEAV LTAANECVGV LLGSLDPSMT IHCDMVITYG 480
LDQLENCQTC GTDYIISVLN LLTLIVEQIN TKLPSSFVEK LFIPSSKLLF LRYHKEKEVV 540
AVAHAVYQAV LSLKNIPVLE TAYKLILGEM TCALNNLLHS LQLPDACSEI KHEAFQNHVF 600
NIDNANFVVI FDLSALTTIG NAKNSLIGMW ALSPTVFALL SKNLMIVHSD LAVHFPAIQY 660
AVLYTLYSHC TRHDHFISSS LSSSSPSLFD GAVISTVTTA TKKHFSIILN LLGILLKKDN 720
LNQDTRKLLM TWALEVAVLM KKSETYAPLF SLPSFHKFSK GLLANTLVED VNICLQACSS 780
LHALSSSLPD DLLQRCVDVC RVQLVHSGTR IRQAFGKLLK SIPLDVVLSN NNHTEIQEIS 840
LALRSHMSKA PSNTFHPQDF SDVISFILYG NSHRTGKDNW LERLFYSCQR LDKRDQSTIP 900
RNLLKTDAVL WQWAIWEAAQ FTVLSKLRTP LGRAQDTFQT IEGIIRSLAA HTLNPDQDVS 960
QWTTADNDEG HGSNQLRLVL LLQYLENLEK LMYNAYEGCA NALTSPPKVI RTFFYTNRQT 1020
CQDWLTRIRL SIMRVGLLAG QPAVTVRHGF DLLTEMKTNS LSQGNELEVT IMMVVEALCE 1080
LHCPEAIQGI AVWSSSAVGK NLLWINSVAQ QAEGRERNEL MVFLCPNSLY CVIVKMTLPI 1140
LSIEAYYNHC SRGHLSSQKD EGDTGEQVQL GVIARTFLFS CHCNCSVTEV IGATSKMKQC 1200
FDCKCSPQWL HRTAIGYFNY RSLSSFESGE FVECTEQLEL LPGENINLLA GGSKEKIDMK 1260
KLLPNMLSPD PRELQKSIEV QLLRSSVFLA TALNHVEQDQ KWQSLTENVV KYLKQTSRIA 1320
IGPLRLSTLT VSQSLPVLST LQLYCSSALE NTVSNRLSTE DCLIPLFSDA LRSCKQHDVR 1380
PWMQALRYTM YQNQLLEKIK EQTVPIRSHL MELGLTAAKF ARKRGNVSLA TRLLAQCSEV 1440
QLGKTTTAQD LVQHFKKLST QGQVDEKWGP ELDIEKTKLL YTAGQSTHAM EMLSSCAISF 1500
CKSAKAEYAV AKSILTLAKW VQAEWKEISG QLRQVYRAQQ QQNLSGLSTL SRNILALIEL 1560
PSANTVGEEH PRIESESTVH IGVGEPDFIL GQLYHLSSVQ APEVAKSWAA LASWAYRWGR 1620
KVVDNASQGE GVRLLPREKS EVQNLLPDTI TEEEKERIYG ILGQAVCRPA GIQDEDITLQ 1680
ITESEDNEDD DMVDVIWRQL ISSCPWLSEL DENATEGVIK VWRKVVDRIF SLYKLSCSAY 1740
FTFLKLNAGQ VLLDEDDPRL HLSHRAEQST DDVIVMATLR LLRLLVKHAG ELRQYLEHGL 1800
ETTPTAPWRG IIPQLFSRLN HPEVYVRQSI CNLLCRVAQD SPHLILYPAI VGTISLSSES 1860
QASGNKYSSA IPTLLGNIQG EELLVSECEG GSPPASQDSN KDEPKSGLNE DQAMMQDCYS 1920
KIVDKLSSAN PTMVLQVQML VAELRRVTVL WDELWLGVLL QQHMYVLRRI QQLEDEVKRV 1980
QNNNTLRKEE KIAIMREKHT ALMKPIVFAL EHVRSITAAP AETPHEKWFQ DNYGDAIDNA 2040
LEKLKTPSNP AKPGSSWIPF KEIMLSLQQR AQKRASYILR LDEISPWLAA MTNTEIALPG 2100
EVSARDTVTI HSVGGTITIL PTKTKPKKLL FLGSDGKSYP YLFKGLEDLH LDERIMQFLS 2160
IVNTMFATIN RQETPRFHAR HYSVTPLGTR SGLIQWVDGA TPLFGLYKRW QQREAALQAQ 2220
KAQDSYQTPQ NPSIVPRPSE LYYSKIGPAL KTVGLSLDVS RRDWPLHVMK AVLEELMEAT 2280
PPNLLAKELW SSCTTPDEWW RVTQSYARST AVMSMVGYII GLGDRHLDNV LIDMTTGEVV 2340
HIDYNVCFEK GKSLRVPEKV PFRMTQNIET ALGVTGVEGV FRLSCEQVLH IMRRGRETLL 2400
TLLEAFVYDP LVDWTAGGEA GFAGAVYGGG GQQAESKQSK REMEREITRS LFSSRVAEIK 2460
VNWFKNRDEM LVVLPKLDSS LDEYLSLQEQ LTDVEKLQGK LLEEIEFLEG AEGVDHPSRT 2520
LQHRYSEHTQ LQTQQRAVQE AIQVKLNEFE QWITHYQAAF NNLEATQLAS LLQEISTQMD 2580
LGPPSYVPAT AFLQNAGQAH LISQCEQLEG EVGTLLQQRR SVLRGCLEQL HHYATVALQY 2640
PKAIFQKHRI EQWKAWMEEL ICNTTVERCQ ELYRKYEMQY APQPPPTVCQ FITATEMTLQ 2700
RYAADINSRL IRQVERLKQE AVTVPVCEDQ LKEIERCIKV FLHENGEEGS LSLASVIISA 2760
LCTLTRRNLM MEGAASSAGE QLVDLTSRDG AWFLEELCSM SGNVTCLVQL LKQCHLVPQD 2820
LDIPNPVEAS EAVHLANGVY TSLQELNSNF RQIIFPEALR CLMKGECTLE SMLHELDSLI 2880
EQTTDGVPLQ TLVESLQAYL RNTAMGLEEE THAHYIDVAR MLHAQYGELI QPRNGSVDET 2940
PKMSAGQMLL VAFDGMFAQV ETAFGLLVEK LNKMEIPVAW RKIDIIREAR STQANFFDDD 3000
NHRQVLEEIF FLKRLQTIKE FFRLCGTFSK TLSGSSSLED QNTVNGPVQI VNVKTLFRNS 3060
CFSEDQMAKP IKAFTADFVR QLLIGLPNQA LGLTLCSFIS ALGVDIIAQV EAKDFGAESK 3120
VSVDDLCKKA VEHNIQVGRF SQLVMNRATV LASSYDTAWK KHDLVRRLET SISSCKTSLQ 3180
RVQLHIAMFQ WQHEDLLINR PQAMSVTPPR SAILTSMKKK LHALSQIETS IGTVQEKLAA 3240
LEASIEQRLK WAGGANPALA PVLQDFEATI AERRNLVLKE SQRANQVTFL CSNIIHFESL 3300
RTRTAEALSL DAALFELIKR CQQMCSFASQ FNSSVSELEL RLLQRVDTTL EHPIGSSEWL 3360
LSAHKQLTQD MSTQRAVQTE KEQQIETVCE TIQSLVDSVK TVLTGHNRQL GDVKHLLKAM 3420
AKDEEAALAD AEDIPYESSV RQFLAEYKSW QDNIQTVLFT LVQAMGQVRS QEHVEMLQEI 3480
TPTLKELKTQ SQSIYNNLVS FASPLVTDAA NECSSPTSSA TYQPSFAAAV RSNTGQKTQP 3540
DVMSQNAKKL IQKNLATSAD TPPSTIPGTG KSIACSPKKA IRDPKTGKAV QERNSYAVSV 3600
WKRVKAKLEG RDVDPNRRMS VAEQVDYVIK EATNLDNLAQ LYEGWTAWV 3649 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
 GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro. 
Interpro
 IPR016024; ARM-type_fold.
 IPR003152; FATC.
 IPR011009; Kinase-like_dom.
 IPR000403; PI3/4_kinase_cat_dom.
 IPR018936; PI3/4_kinase_CS.
 IPR014009; PIK_FAT. 
Pfam
 PF02260; FATC
 PF00454; PI3_PI4_kinase 
SMART
 SM00146; PI3Kc 
PROSITE
 PS51189; FAT
 PS51190; FATC
 PS00916; PI3_4_KINASE_2
 PS50290; PI3_4_KINASE_3 
PRINTS