CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012282
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dihydropyrimidinase-related protein 3 
Protein Synonyms/Alias
 DRP-3; Collapsin response mediator protein 4; CRMP-4; Unc-33-like phosphoprotein 1; ULIP-1 
Gene Name
 DPYSL3 
Gene Synonyms/Alias
 CRMP4; DRP3; ULIP; ULIP1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
293DGTHYWSKNWAKAAAubiquitination[1]
345TAQKAIGKDNFTAIPubiquitination[1, 2]
423AVKIVSAKNHQSAAEubiquitination[1]
511FDLTTTPKGGTPAGSubiquitination[1, 2]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
 Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity). 
Sequence Annotation
 MOD_RES 259 259 Phosphoserine.
 MOD_RES 499 499 Phosphotyrosine (By similarity).
 MOD_RES 509 509 Phosphothreonine; by GSK3.
 MOD_RES 514 514 Phosphothreonine; by GSK3.
 MOD_RES 518 518 Phosphoserine; by GSK3.
 MOD_RES 522 522 Phosphoserine; by DYRK2.
 MOD_RES 541 541 Phosphoserine (By similarity).  
Keyword
 3D-structure; Alternative splicing; Cell projection; Complete proteome; Cytoplasm; Direct protein sequencing; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 570 AA 
Protein Sequence
MSYQGKKNIP RITSDRLLIK GGRIVNDDQS FYADIYMEDG LIKQIGDNLI VPGGVKTIEA 60
NGKMVIPGGI DVHTHFQMPY KGMTTVDDFF QGTKAALAGG TTMIIDHVVP EPESSLTEAY 120
EKWREWADGK SCCDYALHVD ITHWNDSVKQ EVQNLIKDKG VNSFMVYMAY KDLYQVSNTE 180
LYEIFTCLGE LGAIAQVHAE NGDIIAQEQT RMLEMGITGP EGHVLSRPEE LEAEAVFRAI 240
TIASQTNCPL YVTKVMSKSA ADLISQARKK GNVVFGEPIT ASLGIDGTHY WSKNWAKAAA 300
FVTSPPLSPD PTTPDYINSL LASGDLQLSG SAHCTFSTAQ KAIGKDNFTA IPEGTNGVEE 360
RMSVIWDKAV ATGKMDENQF VAVTSTNAAK IFNLYPRKGR ISVGSDSDLV IWDPDAVKIV 420
SAKNHQSAAE YNIFEGMELR GAPLVVICQG KIMLEDGNLH VTQGAGRFIP CSPFSDYVYK 480
RIKARRKMAD LHAVPRGMYD GPVFDLTTTP KGGTPAGSAR GSPTRPNPPV RNLHQSGFSL 540
SGTQVDEGVR SASKRIVAPP GGRSNITSLS 570 
Gene Ontology
 GO:0044297; C:cell body; ISS:UniProtKB.
 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0005615; C:extracellular space; ISS:UniProtKB.
 GO:0031941; C:filamentous actin; ISS:UniProtKB.
 GO:0030426; C:growth cone; ISS:UniProtKB.
 GO:0030027; C:lamellipodium; ISS:UniProtKB.
 GO:0035374; F:chondroitin sulfate binding; ISS:UniProtKB.
 GO:0016812; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides; IEA:InterPro.
 GO:0017124; F:SH3 domain binding; ISS:UniProtKB.
 GO:0051764; P:actin crosslink formation; ISS:UniProtKB.
 GO:0051017; P:actin filament bundle assembly; ISS:UniProtKB.
 GO:0007411; P:axon guidance; TAS:Reactome.
 GO:0071345; P:cellular response to cytokine stimulus; ISS:UniProtKB.
 GO:0030336; P:negative regulation of cell migration; ISS:UniProtKB.
 GO:0010977; P:negative regulation of neuron projection development; ISS:UniProtKB.
 GO:0051491; P:positive regulation of filopodium assembly; ISS:UniProtKB.
 GO:0010976; P:positive regulation of neuron projection development; ISS:UniProtKB.
 GO:0051260; P:protein homooligomerization; ISS:UniProtKB.
 GO:0006208; P:pyrimidine nucleobase catabolic process; IEA:InterPro.
 GO:0048678; P:response to axon injury; ISS:UniProtKB. 
Interpro
 IPR006680; Amidohydro_1.
 IPR011778; Hydantoinase/dihydroPyrase.
 IPR011059; Metal-dep_hydrolase_composite. 
Pfam
 PF01979; Amidohydro_1 
SMART
  
PROSITE
  
PRINTS