CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002043
UniProt Accession
Genbank Protein ID
 X02346 
Genbank Nucleotide ID
Protein Name
 Regulatory protein E2 
Protein Synonyms/Alias
  
Gene Name
 E2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Bovine papillomavirus type 1 
NCBI Taxa ID
 10559 
Lysine Modification
Position
Peptide
Type
References
21TQMQLIEKSSDKLQDacetylation[1]
25LIEKSSDKLQDHILYacetylation[1]
70VVCQERAKQAIEMQLacetylation[1]
84LSLQELSKTEFGDEPacetylation[1]
107DRYMSEPKRCFKKGAacetylation[1]
111SEPKRCFKKGARVVEacetylation[1]
112EPKRCFKKGARVVEVacetylation[1]
149EDGWQLAKAGADGTGacetylation[1]
226PEGDPAGKEAEPAQPacetylation[1]
322NDGFHLLKAGGSCFAacetylation[1]
339SGTANQVKCYRFRVKacetylation[1]
346KCYRFRVKKNHRHRYacetylation[1]
347CYRFRVKKNHRHRYEacetylation[1]
391SQRQDFLKHVPLPPGacetylation[1]
Reference
 [1] Acetylation of conserved lysines in bovine papillomavirus E2 by p300.
 Quinlan EJ, Culleton SP, Wu SY, Chiang CM, Androphy EJ.
 J Virol. 2013 Feb;87(3):1497-507. [PMID: 23152516] 
Functional Description
 E2 regulates viral transcription and DNA replication. Binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. Can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication. 
Sequence Annotation
 MOD_RES 298 298 Phosphoserine.
 MOD_RES 301 301 Phosphoserine.
 MOD_RES 340 340 Cysteine sulfenic acid (-SOH).  
Keyword
 3D-structure; Activator; Complete proteome; DNA replication; DNA-binding; Early protein; Host nucleus; Host-virus interaction; Oxidation; Phosphoprotein; Repressor; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 410 AA 
Protein Sequence
METACERLHV AQETQMQLIE KSSDKLQDHI LYWTAVRTEN TLLYAARKKG VTVLGHCRVP 60
HSVVCQERAK QAIEMQLSLQ ELSKTEFGDE PWSLLDTSWD RYMSEPKRCF KKGARVVEVE 120
FDGNASNTNW YTVYSNLYMR TEDGWQLAKA GADGTGLYYC TMAGAGRIYY SRFGDEAARF 180
STTGHYSVRD QDRVYAGVSS TSSDFRDRPD GVWVASEGPE GDPAGKEAEP AQPVSSLLGS 240
PACGPIRAGL GWVRDGPRSH PYNFPAGSGG SILRSSSTPV QGTVPVDLAS RQEEEEQSPD 300
STEEEPVTLP RRTTNDGFHL LKAGGSCFAL ISGTANQVKC YRFRVKKNHR HRYENCTTTW 360
FTVADNGAER QGQAQILITF GSPSQRQDFL KHVPLPPGMN ISGFTASLDF 410 
Gene Ontology
 GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
 GO:0006275; P:regulation of DNA replication; IEA:InterPro.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 
Interpro
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000427; Papillomavirus_E2_C.
 IPR001866; Papillomavirus_E2_N. 
Pfam
 PF00511; PPV_E2_C
 PF00508; PPV_E2_N 
SMART
  
PROSITE
  
PRINTS