CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015123
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sorcin 
Protein Synonyms/Alias
  
Gene Name
 Sri 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
127VDPQELQKALTTMGFacetylation[1]
127VDPQELQKALTTMGFubiquitination[2]
165DYIACCVKLRALTDSacetylation[1]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Calcium-binding protein that modulates excitation- contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels. 
Sequence Annotation
 DOMAIN 29 64 EF-hand 1.
 DOMAIN 70 103 EF-hand 2.
 DOMAIN 100 135 EF-hand 3.
 DOMAIN 134 169 EF-hand 4.
 MOD_RES 178 178 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Calcium; Complete proteome; Cytoplasm; Membrane; Metal-binding; Phosphoprotein; Reference proteome; Repeat; Sarcoplasmic reticulum. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 198 AA 
Protein Sequence
MAYPGHPGAG GGYYPGGYGG APGGPAFPGQ TQDPLYGYFA AVAGQDGQID ADELQRCLTQ 60
SGIAGGYKPF NLETCRLMVS MLDRDMSGTM GFNEFKELWA VLNGWRQHFI SFDSDRSGTV 120
DPQELQKALT TMGFRLSPQT VNSVAKRYST SGKITFDDYI ACCVKLRALT DSFRRRDSGQ 180
QGVVNFSYDD FIQCVMTV 198 
Gene Ontology
 GO:0042584; C:chromaffin granule membrane; IEA:Compara.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0031982; C:vesicle; IDA:MGI.
 GO:0030018; C:Z disc; IDA:BHF-UCL.
 GO:0005509; F:calcium ion binding; IEA:Compara.
 GO:0006816; P:calcium ion transport; IPI:MGI.
 GO:0042994; P:cytoplasmic sequestering of transcription factor; IMP:BHF-UCL.
 GO:0010459; P:negative regulation of heart rate; IEA:Compara.
 GO:0060315; P:negative regulation of ryanodine-sensitive calcium-release channel activity; IEA:Compara.
 GO:2000678; P:negative regulation of transcription regulatory region DNA binding; IMP:BHF-UCL.
 GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus; IMP:BHF-UCL.
 GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IMP:BHF-UCL.
 GO:0086004; P:regulation of cardiac muscle cell contraction; IEA:Compara.
 GO:1901844; P:regulation of cell communication by electrical coupling involved in cardiac conduction; IEA:Compara.
 GO:1901077; P:regulation of relaxation of muscle; IEA:Compara.
 GO:1901385; P:regulation of voltage-gated calcium channel activity; IEA:Compara. 
Interpro
 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom. 
Pfam
 PF13499; EF_hand_5 
SMART
 SM00054; EFh 
PROSITE
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2 
PRINTS