| Tag | Content |
|---|
| CPLM ID | CPLM-018485 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cytochrome P450 2C70 |
Protein Synonyms/Alias | CYPIIC70 |
Gene Name | Cyp2c70 |
Gene Synonyms/Alias | Cyp2c-70; Cyp2c22 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 28 | NQHRGRGKLPPGPTP | ubiquitination | [1] | | 48 | NILQVDVKNISKSMG | ubiquitination | [1] | | 52 | VDVKNISKSMGMLAK | ubiquitination | [1] | | 59 | KSMGMLAKKYGPVFT | ubiquitination | [1] | | 84 | LHGYKAMKEALIDQG | ubiquitination | [1] | | 97 | QGDEFSDKTDSSLLS | ubiquitination | [1] | | 121 | FSNGETWKQTRRFSL | ubiquitination | [1] | | 234 | GIHNRFLKDVTQQKK | ubiquitination | [1] | | 240 | LKDVTQQKKFILEEI | ubiquitination | [1] | | 241 | KDVTQQKKFILEEIN | ubiquitination | [1] | | 252 | EEINRHQKSLDLSNP | ubiquitination | [1] | | 321 | KYPEVTAKIQEEIAH | ubiquitination | [1] | | 368 | VPIPSPRKTTQDVEF | ubiquitination | [1] | | 405 | KEFPNPEKFDPGHFL | ubiquitination | [1] | | 415 | PGHFLDEKGNFKKSD | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics (By similarity). |
Sequence Annotation | METAL 434 434 Iron (heme axial ligand) (By similarity). |
Keyword | Complete proteome; Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; Oxidoreductase; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 489 AA |
Protein Sequence | MALFIFLGIW LSCFLFLFLW NQHRGRGKLP PGPTPLPIVG NILQVDVKNI SKSMGMLAKK 60
YGPVFTVYLG MKPTVVLHGY KAMKEALIDQ GDEFSDKTDS SLLSRTSQGL GIVFSNGETW 120
KQTRRFSLMV LRSMGMGKKT IEDRIQEEIL YMLDALRKTN GSPCDPSFLL ACVPCNVIST 180
VIFQHRFDYN DQTFQDFMEN FHRKIEILAS PWSQLCSAYP ILYYLPGIHN RFLKDVTQQK 240
KFILEEINRH QKSLDLSNPQ DFIDYFLIKM EKEKHNQKSE FTMDNLVVSI GDLFGAGTET 300
TSSTVKYGLL LLLKYPEVTA KIQEEIAHVI GRHRRPTMQD RNHMPYTDAV LHEIQRYIDF 360
VPIPSPRKTT QDVEFRGYHI PKGTSVMACL TSVLNDDKEF PNPEKFDPGH FLDEKGNFKK 420
SDYFVAFSAG RRACIGEGLA RMEMFLILTN ILQHFTLKPL VKPEDIDTKP VQTGLLHVPP 480
PFELCFIPV 489 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0070330; F:aromatase activity; IEA:EC. GO:0009055; F:electron carrier activity; IEA:InterPro. GO:0020037; F:heme binding; IEA:InterPro. GO:0005506; F:iron ion binding; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |