UniProt Accession

 P5CR2_MOUSE; Q922Q4 

Genbank Protein ID

 BC006882 

Genbank Nucleotide ID

 AAH06882.1 

Protein Name

 Pyrroline-5-carboxylate reductase 2 

Protein Synonyms/Alias

 P5C reductase 2; P5CR 2 

Gene Name

 Pycr2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
307	LAPPSSGKLLTRNPA	acetylation	[1]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (By similarity). 

Sequence Annotation

 NP_BIND 6 11 NADP (By similarity).
 NP_BIND 69 72 NADP (By similarity).
 NP_BIND 95 97 NADP (By similarity).
 BINDING 34 34 NADP; via carbonyl oxygen (By
 BINDING 56 56 NADP (By similarity).
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 304 304 Phosphoserine (By similarity).  

Keyword

 Acetylation; Amino-acid biosynthesis; Complete proteome; Cytoplasm; NADP; Oxidoreductase; Phosphoprotein; Proline biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 320 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004735; F:pyrroline-5-carboxylate reductase activity; IEA:EC.
 GO:0055129; P:L-proline biosynthetic process; IEA:UniProtKB-UniPathway. 

Interpro

 IPR008927; 6-PGluconate_DH_C-like.
 IPR016040; NAD(P)-bd_dom.
 IPR004455; NADP_OxRdtase_F420.
 IPR000304; Pyrroline-COOH_reductase. 

Pfam

 PF03807; F420_oxidored 

SMART

  

PROSITE

 PS00521; P5CR 

PRINTS