UniProt Accession

 PSB5_MOUSE; O55234; Q3UZI1; Q91X53; Q9CWR4; Q9R1P2 

Genbank Protein ID

 AB003304; AB003306; AF060091; AK010441; AK133839; BC012246; BC106144 

Genbank Nucleotide ID

 BAA24916.1; BAA24917.1; AAD50536.1; BAB26942.1; BAE21876.1; AAH12246.1; AAI06145.1 

Protein Name

 Proteasome subunit beta type-5 

Protein Synonyms/Alias

 Macropain epsilon chain; Multicatalytic endopeptidase complex epsilon chain; Proteasome chain 6; Proteasome epsilon chain; Proteasome subunit X 

Gene Name

 Psmb5 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
91	YIASQTVKKVIEINP	ubiquitination	[1]
207	RGYSYDLKVEEAYDL	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the chymotrypsin-like activity of the proteasome and is one of the principal target of the proteasome inhibitor bortezomib (By similarity). Plays a role in the protection against oxidative damage through the Nrf2-ARE pathway. 

Sequence Annotation

 ACT_SITE 60 60 Nucleophile (By similarity).
 BINDING 108 108 Bortezomib; via amide nitrogen (By  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Nucleus; Protease; Proteasome; Reference proteome; Threonine protease; Zymogen. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 264 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005839; C:proteasome core complex; IDA:UniProtKB.
 GO:0008233; F:peptidase activity; IDA:MGI.
 GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
 GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IDA:MGI.
 GO:0006979; P:response to oxidative stress; IDA:MGI. 

Interpro

 IPR000243; Pept_T1A_subB.
 IPR016050; Proteasome_bsu_CS.
 IPR001353; Proteasome_sua/b.
 IPR023333; Proteasome_suB-type. 

Pfam

 PF00227; Proteasome 

SMART

  

PROSITE

 PS00854; PROTEASOME_B_1
 PS51476; PROTEASOME_B_2 

PRINTS

 PR00141; PROTEASOME.