UniProt Accession

 FHL2_MOUSE; O70433; P97448 

Genbank Protein ID

 AF055889; U77040; AF114381; AF153340 

Genbank Nucleotide ID

 AAC12770.1; AAB19211.2; AAD53230.1; AAD34170.1 

Protein Name

 Four and a half LIM domains protein 2 

Protein Synonyms/Alias

 FHL-2; Skeletal muscle LIM-protein 3; SLIM-3 

Gene Name

 Fhl2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
106	SKCQECKKTIMPGTR	ubiquitination	[1]
167	LQCVQCKKPITTGGV	ubiquitination	[1]
220	FCDLYAKKCAGCTNP	ubiquitination	[1]
235	ISGLGGTKYISFEER	ubiquitination	[1]
252	HNDCFNCKKCSLSLV	ubiquitination	[1]
253	NDCFNCKKCSLSLVG	ubiquitination	[1]
277	ILCPDCGKDI*****	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation (By similarity). 

Sequence Annotation

 DOMAIN 40 92 LIM zinc-binding 1.
 DOMAIN 101 153 LIM zinc-binding 2.
 DOMAIN 162 212 LIM zinc-binding 3.
 DOMAIN 221 275 LIM zinc-binding 4.
 ZN_FING 7 31 C4-type (Potential).
 MOD_RES 238 238 Phosphoserine (By similarity).  

Keyword

 Complete proteome; Cytoplasm; LIM domain; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 279 AA 

Protein Sequence

Gene Ontology

 GO:0015629; C:actin cytoskeleton; IEA:Compara.
 GO:0005925; C:focal adhesion; IEA:Compara.
 GO:0031430; C:M band; IEA:Compara.
 GO:0005634; C:nucleus; IDA:BHF-UCL.
 GO:0030018; C:Z disc; IEA:Compara.
 GO:0008134; F:transcription factor binding; ISS:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0055014; P:atrial cardiac muscle cell development; IEP:BHF-UCL.
 GO:0060347; P:heart trabecula formation; IEP:BHF-UCL.
 GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
 GO:0001649; P:osteoblast differentiation; IEP:BHF-UCL.
 GO:0009725; P:response to hormone stimulus; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0055015; P:ventricular cardiac muscle cell development; IEP:BHF-UCL. 

Interpro

 IPR001781; Znf_LIM. 

Pfam

 PF00412; LIM 

SMART

 SM00132; LIM 

PROSITE

 PS00478; LIM_DOMAIN_1
 PS50023; LIM_DOMAIN_2 

PRINTS