CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023694
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 28S ribosomal protein S7, mitochondrial 
Protein Synonyms/Alias
 MRP-S7; S7mt; bMRP-27a; bMRP27a 
Gene Name
 MRPS7 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
7*MAAPAVKVARGWSGubiquitination[1]
42SRYSPEFKDPLIDKEubiquitination[2]
48FKDPLIDKEYYRKPVubiquitination[3, 4]
53IDKEYYRKPVEELTEubiquitination[2, 4]
63EELTEEEKYVRELKKubiquitination[4]
81IKAAPAGKTSSVFEDubiquitination[2, 4]
119IQTLEAVKRKQFEKYubiquitination[4]
125VKRKQFEKYHAASAEubiquitination[3]
163IGLVPILKGGRFYQVubiquitination[3, 4]
208MPEKLSHKLLEAFHNacetylation[5]
221HNQGPVIKRKHDLHKubiquitination[2, 3, 4]
228KRKHDLHKMAEANRAacetylation[5]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861
Functional Description
  
Sequence Annotation
 MOD_RES 208 208 N6-acetyllysine.
 MOD_RES 228 228 N6-acetyllysine.  
Keyword
 Acetylation; Complete proteome; Mitochondrion; Polymorphism; Reference proteome; Ribonucleoprotein; Ribosomal protein; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 242 AA 
Protein Sequence
MAAPAVKVAR GWSGLALGVR RAVLQLPGLT QVRWSRYSPE FKDPLIDKEY YRKPVEELTE 60
EEKYVRELKK TQLIKAAPAG KTSSVFEDPV ISKFTNMMMI GGNKVLARSL MIQTLEAVKR 120
KQFEKYHAAS AEEQATIERN PYTIFHQALK NCEPMIGLVP ILKGGRFYQV PVPLPDRRRR 180
FLAMKWMITE CRDKKHQRTL MPEKLSHKLL EAFHNQGPVI KRKHDLHKMA EANRALAHYR 240
WW 242 
Gene Ontology
 GO:0022627; C:cytosolic small ribosomal subunit; ISS:UniProtKB.
 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0003723; F:RNA binding; ISS:UniProtKB.
 GO:0003735; F:structural constituent of ribosome; ISS:UniProtKB.
 GO:0006412; P:translation; ISS:UniProtKB. 
Interpro
 IPR000235; Ribosomal_S5/S7.
 IPR023798; Ribosomal_S7_dom. 
Pfam
 PF00177; Ribosomal_S7 
SMART
  
PROSITE
 PS00052; RIBOSOMAL_S7 
PRINTS