| Tag | Content |
|---|
| CPLM ID | CPLM-011038 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | MAP/microtubule affinity-regulating kinase 3 |
Protein Synonyms/Alias | ELKL motif kinase 2; EMK-2; MPK-10 |
Gene Name | Mark3 |
Gene Synonyms/Alias | Emk2; Mpk10 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 681 | DMMREIRKVLDANNC | ubiquitination | [1] | | 741 | SGTSIAFKNIASKIA | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Involved in the specific phosphorylation of microtubule- associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (By similarity). |
Sequence Annotation | DOMAIN 56 307 Protein kinase.
DOMAIN 326 365 UBA.
DOMAIN 695 744 KA1.
NP_BIND 62 70 ATP (By similarity).
ACT_SITE 178 178 Proton acceptor (By similarity).
BINDING 85 85 ATP (By similarity).
MOD_RES 42 42 Phosphoserine (By similarity).
MOD_RES 211 211 Phosphothreonine; by LKB1 (By
MOD_RES 383 383 Phosphoserine (By similarity).
MOD_RES 400 400 Phosphoserine (By similarity).
MOD_RES 469 469 Phosphoserine (By similarity).
MOD_RES 549 549 Phosphothreonine (By similarity).
MOD_RES 564 564 Phosphothreonine; by PKC/PRKCZ (By
MOD_RES 598 598 Phosphoserine (By similarity).
MOD_RES 643 643 Phosphoserine (By similarity). |
Keyword | 3D-structure; Alternative splicing; ATP-binding; Cell membrane; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 753 AA |
Protein Sequence | MSTRTPLPTV NERDTENHIS HGDGRQEVTS RTGRSGARCR NSIASCADEQ PHIGNYRLLK 60
TIGKGNFAKV KLARHILTGR EVAIKIIDKT QLNPTSLQKL FREVRIMKIL NHPNIVKLFE 120
VIETEKTLYL IMEYASGGEV FDYLVAHGRM KEKEARAKFR QIVSAVQYCH QKRIVHRDLK 180
AENLLLDADM NIKIADFGFS NEFTVGSKLD TFCGSPPYAA PELFQGKKYD GPEVDVWSLG 240
VILYTLVSGS LPFDGQNLKE LRERVLRGKY RIPFYMSTDC ENLLKRFLVL NPVKRGTLEQ 300
IMKDRWINAG HEEDELKPFV EPELDISDQK RIDIMVGMGY SQEEIQESLS KMKYDEITAT 360
YLLLGRKSAE LDASDSSSSS NLSLAKVRPN SDLSNSTGQS PHHKGQRSVS SSQKQRRYSD 420
HAGPAIPSVV AYPKRSQTST ADSDLKEDGI PSRKSSSSAV GGKGIAPASP MLGNAGNPNK 480
ADIPERKKSP AVPSSNTASG GMTRRNTYVC SERCAADRHS VIQNGKENSA IPDERTPVAS 540
THSISSATTP DRIRFPRGTA SRSTFHGQPR ERRTATYNGP PASPSLSHEA TPLSQTRSRG 600
STNLFSKLTS KLTRRNMSFR FIKRLPTEYE RNGRYEGSSR NVSSEQKDEN REAKPRSLRF 660
TWSMKTTSSM DPSDMMREIR KVLDANNCDY EQRERFLLFC VHGDGHAENL VQWEMEVCKL 720
PRLSLNGVRF KRISGTSIAF KNIASKIANE LKL 753 |
Gene Ontology | GO:0005886; C:plasma membrane; ISS:UniProtKB. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |