UniProt Accession

 CASP6_HUMAN; P55212; Q9BQE7 

Genbank Protein ID

 U20536; U20537; AY254046; BC000305; BC004460 

Genbank Nucleotide ID

 AAC50168.1; AAC50169.1; AAO63494.1; AAH00305.1; AAH04460.1 

Protein Name

 Caspase-6 

Protein Synonyms/Alias

 CASP-6; Apoptotic protease Mch-2; Caspase-6 subunit p18; Caspase-6 subunit p11 

Gene Name

 CASP6 

Gene Synonyms/Alias

 MCH2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
27	TETDAFYKREMFDPA	ubiquitination	[1]
92	VKCFNDLKAEELLLK	ubiquitination	[1]
144	QTLTGLFKGDKCHSL	ubiquitination	[1, 2]
265	QRRVDFCKDPSAIGK	ubiquitination	[3]
273	DPSAIGKKQVPCFAS	ubiquitination	[1]
285	FASMLTKKLHFFPKS	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. 

Sequence Annotation

 ACT_SITE 121 121 By similarity.
 ACT_SITE 163 163 By similarity.
 MOD_RES 257 257 Phosphoserine; by NUAK1.  

Keyword

 3D-structure; Alternative splicing; Apoptosis; Complete proteome; Cytoplasm; Hydrolase; Phosphoprotein; Polymorphism; Protease; Reference proteome; Thiol protease; Zymogen. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 293 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0004197; F:cysteine-type endopeptidase activity; TAS:Reactome.
 GO:0006921; P:cellular component disassembly involved in execution phase of apoptosis; TAS:Reactome.
 GO:0006917; P:induction of apoptosis; TAS:ProtInc.
 GO:0006508; P:proteolysis; IDA:UniProtKB. 

Interpro

 IPR015469; Caspase_6.
 IPR011600; Pept_C14_cat.
 IPR001309; Pept_C14_ICE_p20.
 IPR016129; Pept_C14_ICE_p20_AS.
 IPR002138; Pept_C14_p10.
 IPR002398; Pept_C14_p45.
 IPR015917; Pept_C14_p45_core. 

Pfam

 PF00656; Peptidase_C14 

SMART

 SM00115; CASc 

PROSITE

 PS01122; CASPASE_CYS
 PS01121; CASPASE_HIS
 PS50207; CASPASE_P10
 PS50208; CASPASE_P20 

PRINTS

 PR00376; IL1BCENZYME.