CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021213
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Kinesin light chain 2 
Protein Synonyms/Alias
 KLC 2 
Gene Name
 KLC2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
294NLAVLYGKRGKYKEAubiquitination[1]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). 
Sequence Annotation
 REPEAT 198 231 TPR 1.
 REPEAT 240 273 TPR 2.
 REPEAT 282 315 TPR 3.
 REPEAT 324 357 TPR 4.
 REPEAT 366 399 TPR 5.
 REPEAT 449 482 TPR 6.
 MOD_RES 151 151 Phosphoserine.
 MOD_RES 445 445 Phosphoserine.
 MOD_RES 581 581 Phosphoserine.
 MOD_RES 582 582 Phosphoserine.
 MOD_RES 589 589 Phosphoserine.
 MOD_RES 610 610 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Motor protein; Phosphoprotein; Polymorphism; Reference proteome; Repeat; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 622 AA 
Protein Sequence
MAMMVFPREE KLSQDEIVLG TKAVIQGLET LRGEHRALLA PLVAPEAGEA EPGSQERCIL 60
LRRSLEAIEL GLGEAQVILA LSSHLGAVES EKQKLRAQVR RLVQENQWLR EELAGTQQKL 120
QRSEQAVAQL EEEKQHLLFM SQIRKLDEDA SPNEEKGDVP KDTLDDLFPN EDEQSPAPSP 180
GGGDVSGQHG GYEIPARLRT LHNLVIQYAS QGRYEVAVPL CKQALEDLEK TSGHDHPDVA 240
TMLNILALVY RDQNKYKEAA HLLNDALAIR EKTLGKDHPA VAATLNNLAV LYGKRGKYKE 300
AEPLCKRALE IREKVLGKFH PDVAKQLSNL ALLCQNQGKA EEVEYYYRRA LEIYATRLGP 360
DDPNVAKTKN NLASCYLKQG KYQDAETLYK EILTRAHEKE FGSVNGDNKP IWMHAEEREE 420
SKDKRRDSAP YGEYGSWYKA CKVDSPTVNT TLRSLGALYR RQGKLEAAHT LEDCASRNRK 480
QGLDPASQTK VVELLKDGSG RRGDRRSSRD MAGGAGPRSE SDLEDVGPTA EWNGDGSGSL 540
RRSGSFGKLR DALRRSSEML VKKLQGGTPQ EPPNPRMKRA SSLNFLNKSV EEPTQPGGTG 600
LSDSRTLSSS SMDLSRRSSL VG 622 
Gene Ontology
 GO:0035253; C:ciliary rootlet; IEA:Compara.
 GO:0005829; C:cytosol; ISS:HGNC.
 GO:0016938; C:kinesin I complex; NAS:BHF-UCL.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0043005; C:neuron projection; IEA:Compara.
 GO:0019894; F:kinesin binding; ISS:BHF-UCL.
 GO:0003777; F:microtubule motor activity; IEA:InterPro.
 GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome.
 GO:0008088; P:axon cargo transport; IEA:Compara.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0007018; P:microtubule-based movement; TAS:Reactome. 
Interpro
 IPR002151; Kinesin_light.
 IPR015792; Kinesin_light_repeat.
 IPR015390; Rabaptin_Rab5-bd_dom.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR013105; TPR_2.
 IPR019734; TPR_repeat. 
Pfam
 PF09311; Rab5-bind
 PF07719; TPR_2 
SMART
 SM00028; TPR 
PROSITE
 PS01160; KINESIN_LIGHT
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS
 PR00381; KINESINLIGHT.