CPLM-021318

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-021318

UniProt Accession

IPYR2_HUMAN; Q9H2U2; B4DLP7; F8WDN9; I6L9B6; Q4W5E9; Q6PG51; Q8TBW0; Q96E55; Q9H0T0; Q9NX37; Q9P033; Q9ULX0

Genbank Protein ID

AB026722; AF217187; AK000466; AK297096; AC004066; AC106888; BC022803; BC039462; BC057219; AF161473; AL136655

Genbank Nucleotide ID

BAA84701.1; AAG36781.1; BAA91184.1; BAG59609.1; AAY41040.1; AAH22803.1; AAH39462.2; AAH57219.1; AAF29088.1; CAB66590.2

Protein Name

Inorganic pyrophosphatase 2, mitochondrial

Protein Synonyms/Alias

Pyrophosphatase SID6-306; Pyrophosphate phospho-hydrolase 2; PPase 2

Gene Name

PPA2

Gene Synonyms/Alias

HSPC124

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
126	AKMEIATKEPMNPIK	ubiquitination	[1]

Reference

[1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]

Functional Description

Sequence Annotation

METAL 164 164 Magnesium 1 (By similarity).
METAL 169 169 Magnesium 1 (By similarity).
METAL 169 169 Magnesium 2 (By similarity).
METAL 201 201 Magnesium 1 (By similarity).
MOD_RES 261 261 N6-acetyllysine.
MOD_RES 317 317 Phosphoserine.

Keyword

Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Hydrolase; Magnesium; Metal-binding; Mitochondrion; Phosphoprotein; Polymorphism; Reference proteome; Transit peptide.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

334 AA

Protein Sequence

MSALLRLLRT GAPAAACLRL GTSAGTGSRR AMALYHTEER GQPCSQNYRL FFKNVTGHYI 60
SPFHDIPLKV NSKEDTEAQG IFIDLSKIWE NGIPMKKARN DEYENLFNMI VEIPRWTNAK 120
MEIATKEPMN PIKQYVKDGK LRYVANIFPY KGYIWNYGTL PQTWEDPHEK DKSTNCFGDN 180
DPIDVCEIGS KILSCGEVIH VKILGILALI DEGETDWKLI AINANDPEAS KFHDIDDVKK 240
FKPGYLEATL NWFRLYKVPD GKPENQFAFN GEFKNKAFAL EVIKSTHQCW KALLMKKCNG 300
GAINCTNVQI SDSPFRCTQE EARSLVESVS SSPNKESNEE EQVWHFLGK 349

Gene Ontology

GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0004427; F:inorganic diphosphatase activity; TAS:Reactome.
GO:0000287; F:magnesium ion binding; IEA:InterPro.
GO:0071344; P:diphosphate metabolic process; TAS:Reactome.
GO:0006796; P:phosphate-containing compound metabolic process; IEA:InterPro.
GO:0006418; P:tRNA aminoacylation for protein translation; TAS:Reactome.

Interpro

IPR008162; Pyrophosphatase.

Pfam

PF00719; Pyrophosphatase

SMART

PROSITE

PS00387; PPASE

PRINTS