CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007079
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nuclear polyadenylated RNA-binding protein 3 
Protein Synonyms/Alias
  
Gene Name
 NAB3 
Gene Synonyms/Alias
 HMD1; YPL190C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
340FIGNLPLKNVSKEDLacetylation[1]
425STFISSAKRPFQTESacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 May be required for packaging pre-mRNAs into ribonucleoprotein structures amenable to efficient nuclear RNA processing. Binds to poly(A)+ RNA. Appears to act in the maintenance of CLN3 mRNA levels. 
Sequence Annotation
 DOMAIN 330 401 RRM.
 MOD_RES 86 86 Phosphothreonine.
 MOD_RES 451 451 Phosphothreonine.  
Keyword
 3D-structure; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 802 AA 
Protein Sequence
MSDENHNSDV QDIPSPELSV DSNSNENELM NNSSADDGIE FDAPEEEREA EREEENEEQH 60
ELEDVNDEEE EDKEEKGEEN GEVINTEEEE EEEHQQKGGN DDDDDDNEEE EEEEEDDDDD 120
DDDDDDDEEE EEEEEEEGND NSSVGSDSAA EDGEDEEDKK DKTKDKEVEL RRETLEKEQK 180
DVDEAIKKIT REENDNTHFP TNMENVNYDL LQKQVKYIMD SNMLNLPQFQ HLPQEEKMSA 240
ILAMLNSNSD TALSVPPHDS TISTTASASA TSGARSNDQR KPPLSDAQRR MRFPRADLSK 300
PITEEEHDRY AAYLHGENKI TEMHNIPPKS RLFIGNLPLK NVSKEDLFRI FSPYGHIMQI 360
NIKNAFGFIQ FDNPQSVRDA IECESQEMNF GKKLILEVSS SNARPQFDHG DHGTNSSSTF 420
ISSAKRPFQT ESGDMYNDDN GAGYKKSRRH TVSCNIFVKR TADRTYAIEV FNRFRDGTGL 480
ETDMIFLKPR MELGKLINDA AYNGVWGVVL VNKTHNVDVQ TFYKGSQGET KFDEYISISA 540
DDAVAIFNNI KNNRNNSRPT DYRAMSHQQN IYGAPPLPVP NGPAVGPPPQ TNYYQGYSMP 600
PPQQQQQQPY GNYGMPPPSH DQGYGSQPPI PMNQSYGRYQ TSIPPPPPQQ QIPQGYGRYQ 660
AGPPPQPPSQ TPMDQQQLLS AIQNLPPNVV SNLLSMAQQQ QQQPHAQQQL VGLIQSMQGQ 720
APQQQQQQLG GYSSMNSSSP PPMSTNYNGQ NISAKPSAPP MSHQPPPPQQ QQQQQQQQQQ 780
QQQQPAGNNV QSLLDSLAKL QK 802 
Gene Ontology
 GO:0035649; C:Nrd1 complex; IDA:SGD.
 GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0001068; F:transcription regulatory region RNA binding; IDA:SGD.
 GO:0071041; P:antisense RNA transcript catabolic process; IMP:SGD.
 GO:0071034; P:CUT catabolic process; IMP:SGD.
 GO:0031124; P:mRNA 3'-end processing; IMP:SGD.
 GO:0071028; P:nuclear mRNA surveillance; IMP:SGD.
 GO:0031126; P:snoRNA 3'-end processing; IMP:SGD.
 GO:0034472; P:snRNA 3'-end processing; IMP:SGD.
 GO:0030847; P:termination of RNA polymerase II transcription, exosome-dependent; IDA:SGD.
 GO:0042780; P:tRNA 3'-end processing; IMP:SGD. 
Interpro
 IPR004154; Anticodon-bd.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 
Pfam
 PF00076; RRM_1 
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS