UniProt Accession

 F6Q3K8_MOUSE; F6Q3K8 

Genbank Protein ID

 AC164548 

Genbank Nucleotide ID

  

Protein Name

 Mannose-6-phosphate isomerase 

Protein Synonyms/Alias

  

Gene Name

 Mpi 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
66	LDNRISQKTLGQWIA	ubiquitination	[1]
90	VKNTFNGKLPFLFKV	acetylation	[2, 3]
90	VKNTFNGKLPFLFKV	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 122 AA 

Protein Sequence

Gene Ontology

 GO:0004476; F:mannose-6-phosphate isomerase activity; IDA:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0009298; P:GDP-mannose biosynthetic process; IEA:InterPro.
 GO:0006013; P:mannose metabolic process; IC:MGI. 

Interpro

 IPR001250; Man6P_Isoase-1.
 IPR016305; Mannose-6-P_Isomerase.
 IPR014710; RmlC-like_jellyroll.
 IPR011051; RmlC_Cupin. 

Pfam

 PF01238; PMI_typeI 

SMART

  

PROSITE

  

PRINTS

 PR00714; MAN6PISMRASE.