CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006520
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 RNA-binding protein FUS 
Protein Synonyms/Alias
 75 kDa DNA-pairing protein; Oncogene FUS; Oncogene TLS; POMp75; Translocated in liposarcoma protein 
Gene Name
 FUS 
Gene Synonyms/Alias
 TLS 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
364EFSGNPIKVSFATRRubiquitination[1]
Reference
 [1] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931] 
Functional Description
 Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single- stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity. 
Sequence Annotation
 DOMAIN 285 371 RRM.
 ZN_FING 422 453 RanBP2-type.
 MOD_RES 221 221 Phosphoserine.
 MOD_RES 242 242 Asymmetric dimethylarginine.
 MOD_RES 244 244 Asymmetric dimethylarginine.
 MOD_RES 248 248 Asymmetric dimethylarginine.
 MOD_RES 251 251 Asymmetric dimethylarginine.
 MOD_RES 259 259 Asymmetric dimethylarginine.
 MOD_RES 277 277 Phosphoserine.
 MOD_RES 286 286 Phosphothreonine.
 MOD_RES 377 377 Asymmetric dimethylarginine.
 MOD_RES 383 383 Asymmetric dimethylarginine.
 MOD_RES 386 386 Asymmetric dimethylarginine.
 MOD_RES 388 388 Asymmetric dimethylarginine.
 MOD_RES 394 394 Asymmetric dimethylarginine.
 MOD_RES 407 407 Asymmetric dimethylarginine.
 MOD_RES 473 473 Asymmetric dimethylarginine.
 MOD_RES 476 476 Asymmetric dimethylarginine.
 MOD_RES 481 481 Asymmetric dimethylarginine.
 MOD_RES 485 485 Asymmetric dimethylarginine.
 MOD_RES 487 487 Asymmetric dimethylarginine.
 MOD_RES 491 491 Asymmetric dimethylarginine.
 MOD_RES 495 495 Asymmetric dimethylarginine.
 MOD_RES 498 498 Asymmetric dimethylarginine.
 MOD_RES 503 503 Asymmetric dimethylarginine.  
Keyword
 3D-structure; Alternative splicing; Amyotrophic lateral sclerosis; Chromosomal rearrangement; Complete proteome; Direct protein sequencing; Disease mutation; DNA-binding; Metal-binding; Methylation; Neurodegeneration; Nucleus; Phosphoprotein; Polymorphism; Proto-oncogene; Reference proteome; Repeat; RNA-binding; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 526 AA 
Protein Sequence
MASNDYTQQA TQSYGAYPTQ PGQGYSQQSS QPYGQQSYSG YSQSTDTSGY GQSSYSSYGQ 60
SQNSYGTQST PQGYGSTGGY GSSQSSQSSY GQQSSYPGYG QQPAPSSTSG SYGSSSQSSS 120
YGQPQSGSYS QQPSYGGQQQ SYGQQQSYNP PQGYGQQNQY NSSSGGGGGG GGGGNYGQDQ 180
SSMSSGGGSG GGYGNQDQSG GGGSGGYGQQ DRGGRGRGGS GGGGGGGGGG YNRSSGGYEP 240
RGRGGGRGGR GGMGGSDRGG FNKFGGPRDQ GSRHDSEQDN SDNNTIFVQG LGENVTIESV 300
ADYFKQIGII KTNKKTGQPM INLYTDRETG KLKGEATVSF DDPPSAKAAI DWFDGKEFSG 360
NPIKVSFATR RADFNRGGGN GRGGRGRGGP MGRGGYGGGG SGGGGRGGFP SGGGGGGGQQ 420
RAGDWKCPNP TCENMNFSWR NECNQCKAPK PDGPGGGPGG SHMGGNYGDD RRGGRGGYDR 480
GGYRGRGGDR GGFRGGRGGG DRGGFGPGKM DSRGEHRQDR RERPY 525 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; TAS:ProtInc.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0008219; P:cell death; IEA:UniProtKB-KW.
 GO:0000398; P:mRNA splicing, via spliceosome; TAS:Reactome. 
Interpro
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom.
 IPR001876; Znf_RanBP2. 
Pfam
 PF00076; RRM_1
 PF00641; zf-RanBP 
SMART
 SM00360; RRM
 SM00547; ZnF_RBZ 
PROSITE
 PS50102; RRM
 PS01358; ZF_RANBP2_1
 PS50199; ZF_RANBP2_2 
PRINTS