UniProt Accession

 PTHP_ECOLI; P0AA04; P05525; P07006 

Genbank Protein ID

 M10425; J02796; M21994; M21451; U00096; AP009048 

Genbank Nucleotide ID

 AAA24438.1; AAA24440.1; AAA24384.1; AAA23655.1; AAC75468.1; BAA16289.1 

Protein Name

 Phosphocarrier protein HPr 

Protein Synonyms/Alias

 Histidine-containing protein 

Gene Name

 ptsH 

Gene Synonyms/Alias

 hpr; b2415; JW2408 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
24	RPAAQFVKEAKGFTS	acetylation	[1, 2]
27	AQFVKEAKGFTSEIT	acetylation	[1, 2]
40	ITVTSNGKSASAKSL	acetylation	[2]
72	AEGEDEQKAVEHLVK	acetylation	[1, 2]
79	KAVEHLVKLMAELE*	acetylation	[1, 2]

Reference

 [1] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111]
 [2] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the permease (enzymes II/III). 

Sequence Annotation

 DOMAIN 1 85 HPr.
 ACT_SITE 15 15 Pros-phosphohistidine intermediate.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Kinase; Phosphotransferase system; Reference proteome; Serine/threonine-protein kinase; Sugar transport; Transferase; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 85 AA 

Protein Sequence

Gene Ontology

 GO:0019197; C:phosphoenolpyruvate-dependent sugar phosphotransferase complex; IDA:EcoCyc.
 GO:0008047; F:enzyme activator activity; IDA:EcoliWiki.
 GO:0016301; F:kinase activity; IDA:EcoCyc.
 GO:0008965; F:phosphoenolpyruvate-protein phosphotransferase activity; IDA:EcoCyc.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
 GO:0005351; F:sugar:hydrogen symporter activity; IEA:InterPro.
 GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IDA:EcoCyc.
 GO:0045819; P:positive regulation of glycogen catabolic process; IDA:EcoCyc. 

Interpro

 IPR001020; PTS_HPr_His_P_site.
 IPR005698; PTS_HPr_prot.
 IPR000032; PTS_HPr_prot-like.
 IPR002114; PTS_HPr_Ser_P_site. 

Pfam

 PF00381; PTS-HPr 

SMART

  

PROSITE

 PS51350; PTS_HPR_DOM
 PS00369; PTS_HPR_HIS
 PS00589; PTS_HPR_SER 

PRINTS

 PR00107; PHOSPHOCPHPR.