CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007696
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 26S proteasome regulatory subunit RPN11 
Protein Synonyms/Alias
 Protein MPR1 
Gene Name
 RPN11 
Gene Synonyms/Alias
 MPR1; YFR004W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
12QRLMMNSKVGSADTGubiquitination[1]
205SLNIDYHKTAKETKMubiquitination[1]
233KMYDYEEKEESNLAAubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. 
Sequence Annotation
 MOD_RES 1 1 N-acetylmethionine.  
Keyword
 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Proteasome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 306 AA 
Protein Sequence
MERLQRLMMN SKVGSADTGR DDTKETVYIS SIALLKMLKH GRAGVPMEVM GLMLGEFVDD 60
YTVNVVDVFA MPQSGTGVSV EAVDDVFQAK MMDMLKQTGR DQMVVGWYHS HPGFGCWLSS 120
VDVNTQKSFE QLNSRAVAVV VDPIQSVKGK VVIDAFRLID TGALINNLEP RQTTSNTGLL 180
NKANIQALIH GLNRHYYSLN IDYHKTAKET KMLMNLHKEQ WQSGLKMYDY EEKEESNLAA 240
TKSMVKIAEQ YSKRIEEEKE LTEEELKTRY VGRQDPKKHL SETADETLEN NIVSVLTAGV 300
NSVAIK 306 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0008541; C:proteasome regulatory particle, lid subcomplex; IDA:SGD.
 GO:0034515; C:proteasome storage granule; IDA:SGD.
 GO:0008237; F:metallopeptidase activity; ISS:SGD.
 GO:0004843; F:ubiquitin-specific protease activity; IMP:SGD.
 GO:0000266; P:mitochondrial fission; IMP:SGD.
 GO:0016559; P:peroxisome fission; IMP:SGD.
 GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IMP:SGD.
 GO:0016579; P:protein deubiquitination; IMP:SGD. 
Interpro
 IPR000555; JAB1_Mov34_MPN_PAD1.
 IPR024969; Rpn11/EIF3F_C. 
Pfam
 PF01398; JAB
 PF13012; MitMem_reg 
SMART
 SM00232; JAB_MPN 
PROSITE
  
PRINTS